David Duchovny and Drea de Matteo in Californication (2007)

Teri Hatcher, Drea de Matteo, and John Barrowman in Desperate Housewives (2004)

Drea de Matteo in Desperate Housewives (2004)

Drea de Matteo and John Barrowman in Desperate Housewives (2004)

Drea de Matteo and Suzanne Costollos in Desperate Housewives (2004)

Heidi Klum, Drea de Matteo, and Eva Longoria in Desperate Housewives (2004)

Drea de Matteo and Eva Longoria in Desperate Housewives (2004)

Drea de Matteo and Alex Carter in Don't Sleep (2017)

Jimmy Smits, Drea de Matteo, Mark Boone Junior, Kim Coates, Tommy Flanagan, Charlie Hunnam, Theo Rossi, Kurt Sutter, and First Aid Kit in Conan (2010)

Drea de Matteo and Vincent Laresca in Shades of Blue (2016)

Ray Liotta, Drea de Matteo, Santino Fontana, Hampton Fluker, and Dayo Okeniyi in Shades of Blue (2016)

Jennifer Lopez, Ray Liotta, Drea de Matteo, Santino Fontana, and Hampton Fluker in Shades of Blue (2016)

Drea de Matteo, Vincent Laresca, Hampton Fluker, and Sarah Jeffery in Shades of Blue (2016)

Jennifer Lopez, Ray Liotta, Drea de Matteo, Vincent Laresca, Santino Fontana, Hampton Fluker, and Dayo Okeniyi in Shades of Blue (2016)

Jennifer Lopez, Ray Liotta, and Drea de Matteo in Shades of Blue (2016)

Drea de Matteo and Theo Rossi in Sons of Anarchy (2008)

Katey Sagal, Drea de Matteo, and Charlie Hunnam in Sons of Anarchy (2008)

Drea de Matteo and Michael Imperioli in The Sopranos (1999)

Drea de Matteo and Ivan Martin in Sleepwalk (2000)

Ethan Hawke, Natalie Portman, Julie Christie, Drea de Matteo, Orlando Bloom, Bradley Cooper, and Shia LaBeouf in New York, I Love You (2008)

Ethan Hawke, Natalie Portman, Robin Wright, Julie Christie, Drea de Matteo, Bradley Cooper, and Shia LaBeouf in New York, I Love You (2008)

Ethan Hawke, Laurence Fishburne, John Leguizamo, Maria Bello, Drea de Matteo, and Ja Rule in Assault on Precinct 13 (2005)

Matt LeBlanc and Drea de Matteo in Joey (2004)