Matthew Staton Bomer was born in Webster Groves, Greater St. Louis, Missouri, to Elizabeth Macy (Staton) and John O'Neill Bomer IV, a Dallas Cowboys draft pick. Matt was raised in Spring, Texas, and educated at Klein High School, near Houston. After school, he attended Carnegie Mellon University in Pittsburgh, Pennsylvania, graduating with a Bachelor of Fine Arts degree. Bomer then relocated to New York to forge a career in acting.
Theater work followed, but his television break came with a small part in All My Children (1970). This lead to a reoccurring role in Guiding Light (1952) as murderous Ben Reade. Further success in TV followed including parts in Tru Calling (2003), Chuck (2007) and the lead role in Traveler (2007) . Bomer also scored film roles in projects such as Flightplan (2005) and The Texas Chainsaw Massacre: The Beginning (2006). In 2009, he was cast in the lead role of criminal mastermind Neal Caffrey in Fox's White Collar (2009).