Born and raised in Union City, New Jersey. Darlene studied at City University Of New York, The Lee Strasberg Institute and she's a lifetime member of the The Actor's Studio.
Her acting career began on the small screen with the contract role of "Anita Santos" on All My Children. From there her work included Crossing Jordan, NYPD Blue, Nip/ Tuck, Las Vegas, Medium, Ugly Betty, Bones, Criminal Minds, Strong Medicine, Soccer Moms (pilot), How I Met Your Mother, Trauma, A Gifted Man and more.
Darlene's film credits include Starsky & Hutch, the German comedy 100 Pro, I Now Pronounce You Chuck and Larry, Star Trek under the direction of J.J. Abrams and more.