- Following the film Platoon (1986), Charlie Sheen - who starred in the film - did a TV interview and credits David with saving his life. While shooting in an open-doored Huey gunship, the helicopter banked too hard, and Sheen was thrown towards - and would have gone through - the open door. David grabbed Sheen by the back and pulled him back in.
- Frequent voice collaborator with fellow voice actor Ron Perlman. Computer games: Fallout: A Post-Nuclear Role-Playing Game (1997), Lords of EverQuest (2003), Halo 2 (2004), Halo 3 (2007). Animated series: Aladdin (1994), Fantastic Four: The Animated Series (1994), Justice League (2001), Teen Titans (2003). And they have both had a guest appearance on the television series The Outer Limits (1995).
- Very popular voice-over actor.
- In February 2010, he became the first actor to provide his voice for two films nominated for Academy Awards for Best Animated Feature. He played the role of The Cat in Coraline (2009) and the villain Dr. Facilier in The Princess and the Frog (2009).
- Took over as narrator for the documentary series City Confidential (1998) after the death of Paul Winfield.
- Profiled in "Character Kings: Hollywood's Familiar Faces Discuss the Art & Business of Acting" by Scott Voisin (2009).
- Nominated for Broadway's 1992 Tony Award as Best Actor (Featured Role - Musical) for "Jelly's Last Jam".
- He was awarded the 1996 Drama Logue Award for Performance for "Seven Guitars" at the Ahmanson Theatre in Los Angeles, California.
- Has three children: daughters Ruby and Maelee with his current wife and a son Owen from his previous marriage to Margit.
- Has portrayed both President and Vice President of the United States in instances of aliens threatening to destroy Earth in his voiceover work. Played himself as Vice President Keith David in the video game Saints Row 4 (2013) and played "The President" in season 2, episode 5 of Rick & Morty titled, "Get Schwifty". Mr. David's success rate stands at 50%. As President, Earth survived the "Cromulon's" test. Against the Zin in Saint's Row 4 however, the Earth did not fare quite as well, although some of humanity (those abducted by the Zin) did survive.
- He was awarded the 1991 Drama Logue Award for Outstanding Lead Performance for "Jelly's Last Jam" at the Mark Taper Forum Theatre in Los Angeles, California.
- A Science Fiction Hall of Fame inductee 2017.
- Studied acting with Michael Howard in New York City.
- He appeared in Volcano (1997) and the following year, Armageddon (1998). The former "rivaled" with Dante's Peak (1997), the latter "rivaled" with Deep Impact (1998). Due to the fact of being similar-plotted movies released around the same time. The ones Keith appeared in were lesser scientifically accurate than the ones they "rivaled" with.
- Parents are Lester and Dolores Williams.
- The hosts of The Snark Tank podcast would offer him the chance to voice the introduction to the podcast.
- His ex-wife attended Hunter College of the City University of New York (CUNY) with Lisa Nicole Carson where they both appeared (and worked backstage) in theater department productions.
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