Loretta Devine and James Pickens Jr. in Grey's Anatomy (2005)

Jennifer Love Hewitt and Loretta Devine in The Client List (2011)

Jennifer Love Hewitt, Loretta Devine, and Erin Cardillo in The Client List (2011)

Jennifer Love Hewitt, Loretta Devine, Alicia Lagano, Naturi Naughton, and Desi Lydic in The Client List (2011)

Loretta Devine and Ross Mathews in RuPaul's Drag Race (2009)

Loretta Devine, RuPaul, Michelle Visage, Ross Mathews, and Santino Rice in RuPaul's Drag Race (2009)

Joni Avery, Loretta Devine, and James Pickens Jr. in Grey's Anatomy (2005)

Tatyana Ali, Taylor Dayne, Loretta Devine, Daniel Franzese, A.J. McLean, Thom Filicia, Mark Indelicato, Kevin McHale, and Jenna Ushkowitz in RuPaul's Secret Celebrity Drag Race (2020)

Loretta Devine and Omari Hardwick in Spell (2020)

Tatyana Ali and Loretta Devine in Jingle Belle (2018)

Loretta Devine and Amber Stevens West in The Carmichael Show (2015)

David Alan Grier, Loretta Devine, and Lil Rel Howery in The Carmichael Show (2015)

David Alan Grier, Loretta Devine, Tiffany Haddish, and Lil Rel Howery in The Carmichael Show (2015)

Loretta Devine and Kim Rhodes in Supernatural (2005)

Jensen Ackles and Loretta Devine in Supernatural (2005)

Loretta Devine and Adrian Holmes in Supernatural (2005)

Jensen Ackles, Loretta Devine, and Kim Rhodes in Supernatural (2005)

Clifton Davis, Loretta Devine, Sherman Hemsley, Anna Maria Horsford, Barbara Montgomery, Roz Ryan, and Tajh Abdul-Samad in Amen (1986)

David Alan Grier, Loretta Devine, Amber Stevens West, Tiffany Haddish, Lil Rel Howery, and Jerrod Carmichael in The Carmichael Show (2015)

David Alan Grier and Loretta Devine in The Carmichael Show (2015)

Majandra Delfino, Loretta Devine, and Raven-Symoné in State of Georgia (2011)

David Alan Grier, Loretta Devine, Amber Stevens West, Tiffany Haddish, and Lil Rel Howery in The Carmichael Show (2015)

David Alan Grier, Loretta Devine, Amber Stevens West, and Jerrod Carmichael in The Carmichael Show (2015)

Angela Bassett, Whitney Houston, Lela Rochon, and Loretta Devine in Waiting to Exhale (1995)

Angela Bassett, Whitney Houston, Taye Diggs, Sanaa Lathan, Lela Rochon, and Loretta Devine in Waiting to Exhale (1995)

Debbi Morgan, Loretta Devine, Kimberly Elise, and Clyde Goins in Woman Thou Art Loosed (2004)

Debbi Morgan, Loretta Devine, and Kimberly Elise in Woman Thou Art Loosed (2004)