After graduating with a degree in History from Duke University in 1984, Rene Echevarria moved to New York City to pursue a career in theater. He joined the Circle Repertory Lab Company in 1985, where he assistant directed a production of Victor Muniz' play "Darts", and acted in a production of Gorky's "Lower Depths". In 1986, he acted in Kristin McCloy's play "Isosceles" at the Chelsea Theater, and in 1987, he was seen in the La Mama Theater adaptation of Aeschuylus' "Oresteia". He collaborated with Kristin McCloy on the full-length play "Prepared", which was presented at the World's End Theater in London during 1988, and went on to be performed at that year's Edinburgh Festival. In 1989, he wrote a spec script for 'Star Trek: The Next Generation' called "The Offspring". He became a Story Editor for the show's sixth season, and Executive Story Editor during its seventh and final season, for which the show received an Emmy Nomination for Best Dramatic Series. Echevarria then took the job of Co-Supervising Producer on Star Trek: Deep Space Nine (1993). His 30-plus episodes of Star Trek have won him a Humanitas nomination, a Peabody nomination, two Hugo nominations, and a NASA Vision award for best depiction of humanity's future in space. In 1994, he received a Special Achievement award from the Latino Media Organization HAMAS.
With fellow Star Trek Producer 'Ken Biller', he developed the scenario for _Star Trek: The Experience (1998)_, a theme park attraction built by Paramount Parks at the Las Vegas Hilton. In 1999-2000, Echevarria was supervising producing on Paramount's short-lived but critically praised Now and Again (1999) on CBS. In July 2000, he signed on as co-executive producer of Dark Angel (2000) the science fiction series created by James Cameron for the Fox network, as part of an overall multiyear deal with 20th Century Fox Television to develop new projects for the studio.