Murray Gold has been nominated for a BAFTA six times in the category Best Original Television Music, for Vanity Fair (1999), Queer as Folk (2000), Casanova (2006), Doctor Who (2008) and A Very English Scandal (2019). His score for the BAFTA winning film Kiss of Life was awarded the Mozart Prize of the 7th Art by a French jury at Aubagne in 2003. He has also been nominated five times by the Royal Television Society in categories relating to music for television, winning twice.

Murray has worked extensively with writer/director Russell T Davies on projects such as A Very English Scandal (starring Hugh Grant), Casanova (starring David Tennant), The Second Coming (starring Christopher Eccleston), Cucumber and Queer as Folk, series 1 and 2. He has also scored the C4 period drama The Devil's Whore, the BBC series The Musketeers, BBC Natural History series Life Story, the crime drama Scott & Bailey and wrote the theme tune for the Channel 4 hit series Shameless. More recently Murray scored Lookout Point's upcoming 8-part drama Gentleman Jack for BBC One and HBO.

Between 2005 and 2018, Murray served as musical director for the wildly successful re-imagining of the BBC's Doctor Who. In this capacity, he created a new arrangement of the show's theme (originally composed by Ron Grainer) and composed the score for 10 entire series. Murray also created, arranged and orchestrated three special live concerts for the music from Doctor Who. The first, Doctor Who: A Celebration, was played at the Millennium Centre in Cardiff in 2006; the second, the 2008 Doctor Who Prom, was part of the BBC Proms on 24 July 2008 at the Royal Albert Hall in London; the third, the 2010 Doctor Who Prom, was part of the BBC Proms hold in 2010 at the Royal Albert Hall again. In March 2010, Murray's Doctor Who soundtrack entered UK radio station Classic FM's Hall of Fame as that year's second highest new entry.

Gold has scored a number of British and American films, including Death at a Funeral directed by Frank Oz and Mischief Night, directed by Penny Woolcock. Other projects include 2006's film Alien Autopsy and the 2009 drama feature Veronika Decides to Die.

In 2001, his radio play Electricity was given the Imison Award - named after former BBC radio drama script editor Richard Imison - for best new. It subsequently transferred to the West Yorkshire Playhouse and was performed with Christopher Eccleston in the lead role. Others of his plays include 50 Revolutions performed by the Oxford Stage Company at the Whitehall Theatre, London in 2000 and Resolution at Battersea Arts Centre in 1994. Gold also wrote the radio play Kafka: The Musical, broadcast on Easter Sunday 2011 on BBC Radio 3, starring David Tennant. It won the 2013 Tinniswood Award for the Best Original Radio Drama.