Chris Evans, Chyler Leigh, and Eric Christian Olsen in Not Another Teen Movie (2001)

Jessica Capshaw, Eric Dane, Chyler Leigh, Kevin McKidd, Sandra Oh, Ellen Pompeo, Sara Ramirez, and Chandra Wilson in Grey's Anatomy (2005)

Chyler Leigh and Melissa Benoist in Supergirl (2015)

Chyler Leigh and Jesse Williams in Grey's Anatomy (2005)

Chyler Leigh and Emma Tremblay in Supergirl (2015)

Rick Gonzalez, Chyler Leigh, Wentworth Miller, Dominic Purcell, David Ramsey, Brandon Routh, Nick Zano, Stephen Amell, Caity Lotz, Grant Gustin, Tala Ashe, Juliana Harkavy, Echo Kellum, and Maisie Richardson-Sellers in DC's Legends of Tomorrow (2016)

Chyler Leigh, Melissa Benoist, and Chris Wood in Supergirl (2015)

David Harewood, Chyler Leigh, Melissa Benoist, Jeremy Jordan, and Chris Wood in Supergirl (2015)

Chyler Leigh, Jeremy Jordan, and Amy Jackson in Supergirl (2015)

Helen Slater and Chyler Leigh in Supergirl (2015)

Jaime Pressly, Chris Evans, Eric Jungmann, Chyler Leigh, Deon Richmond, and Cerina Vincent in Not Another Teen Movie (2001)

Mia Kirshner, Jaime Pressly, Chris Evans, Eric Jungmann, Chyler Leigh, Ron Lester, Cody McMains, Eric Christian Olsen, Deon Richmond, and Cerina Vincent in Not Another Teen Movie (2001)

Amanda Peet, Steve Zahn, Jason Biggs, Jaime Pressly, Jack Black, Chris Evans, and Chyler Leigh in Loser (2000)

Jaime Pressly, Chris Evans, Chyler Leigh, and Cerina Vincent in Not Another Teen Movie (2001)