Turned down a role in Desperado (1995) because he does not want to be in films that promoted negative images of Latinos.
Was a disc jockey on MEGA 92.3 in Los Angeles, California.
Attended and graduated from San Fernando High School in Los Angeles, California (1979).
On June 8, 2002, he hosted the Seventh Annual Florida Sports Awards from Jacksonville's Times-Union Center for the Performing Arts.
Sandra Bullock gave George his break into television stardom with her own production company when she sent out a scout to check the clubs for Latino talent because there were no Hispanic shows on television.
On October 10-12, 2003, he became one of the few comedians to be able to sell-out Los Angeles' historic Universal Amphitheater for three straight nights.
His live comedy album, "Team Leader" (2003), was nominated for the "Best Comedy Album" Grammy in 2004, up against albums by Garrison Keillor, 'Weird Al' Yankovic, Margaret Cho and David Cross.
George Lopez, his character on George Lopez (2002), was ranked #18 in TV Guide's list of the "50 Greatest TV Dads of All Time" [June 20, 2004 issue].
One of the many witnesses in the Michael Jackson trial.
On April 25, 2005, he had a successful kidney transplant surgery using an organ donated by his wife, Ann Serrano Lopez.
Only the fourth Latino ever to head a sitcom, the first three being Desi Arnaz (I Love Lucy (1951)), Freddie Prinze (Chico and the Man (1974)) and Paul Rodriguez (a.k.a. Pablo (1984)).
Received a star on the Hollywood Walk of Fame at 6801 Hollywood Boulevard in Hollywood, California on March 29, 2006.
Has one daughter with Ann Serrano Lopez: Mayan Lopez (born 1995).
In 2007, Forbes magazine estimated his earnings for the year at $26 million.
Good friends with WWE Hall of Famer Pedro Morales and Andy Garcia and his family.
Has a philanthropic organization called The Lopez Foundation.
His late-night talk show, Lopez Tonight (2009), abruptly ended on August 12, 2011, prior to the start of his third season.
Auditioned for a role in Blood In, Blood Out (1993).
In May 2010, the National Enquirer ran a story on George Lopez having cheated on his wife with prostitutes. A professional escort, who uses the name Tiffany, told the Enquirer that in 2009 Lopez had gotten her number from a website she uses to advertise her services and that he called her to arrange a meeting at his hotel room. Tiffany said Lopez paid her $500 to have sex with him. She also said that Lopez told her he liked to use the same hookers regularly 'that way, I always know what I'm going to get'. Tiffany went on to add that she later found out he had hired a fellow hooker, by the name of Samantha, the same day he had seen her. The prostitute passed a polygraph lie detector test she took after making these claims. When asked to comment on having had sex with Tiffany and Samantha, Lopez denied ever having met with them. The news of George Lopez cheating on his wife with prostitutes came as a shock, because his wife had saved his life by donating a kidney to him in 2005, after Lopez nearly died in 2004 from kidney failure.
On February 27, 2014, George Lopez was arrested for public intoxication after getting drunk and falling asleep on the floor of the Ceasars Windsor casino in Ontario, Canada. The casino's security alerted law enforcement upon finding him sleeping on the casino floor. Lopez had performed at the casino earlier that day in the evening. He had another show the following day, which the casino duly canceled. Soon after, a photograph of a drunken and passed out asleep Lopez was quickly circulated around the web.
Has had an ongoing feud for years with CHiPs (1977) star, Erik Estrada, because Estrada wouldn't sign an autograph nor shake his hand when Lopez was a child while Estrada was filming an episode of CHiPs near Lopez's neighborhood. Since then, Lopez vowed to make Estrada pay. In 2011, Estrada told a Miami radio show, The Enrique Santos Show, that he didn't remember ignoring Lopez, but that he was tired of Lopez thrashing his name and that he had seen Lopez at a church event and challenged him to a fight and that Lopez backed down, stating, "I'm a comedian, not a fighter.".
In 2010, Mexican radio show personality, La Vozalona (Marlene Quinto), as part of the Mexican radio show, "El Show de Don Cheto", said that she had met George Lopez at a Cuban restaurant in which she was eating with a friend and when she saw that he had finished eating and seemed on his way out, she approached him near the exit of the restaurant while he was taking a picture with a fan and told him that she wanted a picture with him, to which she said he became very rude and disrespectful and told her she had to wait and that "even Mexicans have manners and say please". Confused, La Vozalona said she told Lopez she was a big fan and one of his many followers on Twitter, to which she said that he told her to shut up and take the picture already. La Vozalona said she told Lopez to stop being rude, because she could "burn" him and that he responded, "What, you think I care?". This was very surprising for many and many considered Lopez a big hypocrite for the incident, considering he's been criticizing and ridiculing Erik Estrada for many years for not shaking his hand and refusing to sign an autograph when Lopez was 17, while Estrada filmed an episode of CHiPs near Lopez's neighborhood.
Friends with Steve Harvey, Eva Longoria, Constance Marie, Oscar De La Hoya, Cedric the Entertainer, D.L. Hughley, Eddie Griffin, and Charlie Murphy.
He has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Real Women Have Curves (2002).