Patti LuPone in American Horror Story (2011)

Patti LuPone and Denis O'Hare in American Horror Story (2011)

Susan Sarandon, Judah Friedlander, and Patti LuPone in 30 Rock (2006)

Susan Sarandon, Tina Fey, Judah Friedlander, and Patti LuPone in 30 Rock (2006)

Judah Friedlander and Patti LuPone in 30 Rock (2006)

Jane Krakowski, Anita Gillette, Jan Hooks, Patti LuPone, John Lutz, Tracy Morgan, Novella Nelson, Elaine Stritch, Cheyenne Jackson, and Kyoko Bruguera in 30 Rock (2006)

Alec Baldwin, Judah Friedlander, and Patti LuPone in 30 Rock (2006)

Alec Baldwin and Patti LuPone in 30 Rock (2006)

Patti LuPone, Aida Turturro, and Alicia Renee Washington in The 24 Hour Woman (1999)

Tovah Feldshuh and Patti LuPone in Crazy Ex-Girlfriend (2015)

Patti LuPone, Debra Jo Rupp, Joe Locke, Ali Ahn, and Sasheer Zamata in Agatha All Along (2024)

Patti LuPone, Debra Jo Rupp, Kathryn Hahn, Ali Ahn, and Sasheer Zamata in Agatha All Along (2024)

Patti LuPone, Debra Jo Rupp, Kathryn Hahn, and Sasheer Zamata in Agatha All Along (2024)

Patti LuPone, Kathryn Hahn, Joe Locke, Aubrey Plaza, Ali Ahn, and Sasheer Zamata in Agatha All Along (2024)

Elon Gold and Patti LuPone in In-Laws (2002)

John Leguizamo and Patti LuPone in Patti LuPone & John Leguizamo (2023)

Patti LuPone and Cynthia Nixon in Cynthia Nixon & Patti LuPone (2022)

Patti LuPone and Rachel Bloom in Crazy Ex-Girlfriend (2015)

Patti LuPone in Crazy Ex-Girlfriend (2015)

Kellie Martin, Patti LuPone, and Ryan Michelle Bathe in Army Wives (2007)

Danny DeVito and Patti LuPone in The Comedian (2016)

Patti LuPone and Martin Vidnovic in Love Cycle: A Soap Operetta (1984)

Patti LuPone and Eva Green in Penny Dreadful (2014)

Kellie Martin, Chris Burke, Monique Lanier, Patti LuPone, and Bill Smitrovich at an event for Life Goes On (1989)

Bebe Neuwirth, Cyndi Lauper, Patti LuPone, and Chita Rivera

Randy Quaid and Patti LuPone in LBJ: The Early Years (1987)

Kellie Martin, Chris Burke, Patti LuPone, Tracey Needham, and Bill Smitrovich in Life Goes On (1989)