Bruce Boxleitner, Victor Garber, Lisa Banes, Scott Grimes, Seth MacFarlane, Adrianne Palicki, and Anne Winters in Gently Falling Rain (2022)

Seth MacFarlane in Saturday Night Live (1975)

Russell Crowe and Seth MacFarlane in The Loudest Voice (2019)

Seth MacFarlane in Seth MacFarlane (2019)

Seth MacFarlane and Adrianne Palicki in The Orville (2017)

Seth MacFarlane, Peter Macon, Jessica Szohr, and Adrianne Palicki in The Orville (2017)

Penny Johnson Jerald, Seth MacFarlane, Peter Macon, and Adrianne Palicki in The Orville (2017)

Mark Wahlberg and Seth MacFarlane in Ted 2 (2015)

Mark Wahlberg, Seth MacFarlane, and Amanda Seyfried in Ted 2 (2015)

Seth MacFarlane and Amanda Seyfried in Ted 2 (2015)

Mark Wahlberg and Seth MacFarlane in Ted (2012)

Mark Wahlberg, Mila Kunis, and Seth MacFarlane in Ted (2012)

Mark Wahlberg, Sam J. Jones, and Seth MacFarlane in Ted (2012)

Seth MacFarlane and Kristen Wiig in The Late Late Show with James Corden (2015)

Scott Grimes, Seth MacFarlane, Adrianne Palicki, J. Lee, and Halston Sage in The Orville (2017)

Seth MacFarlane and Adrianne Palicki in Electric Sheep (2022)

Seth MacFarlane and Anne Winters in Electric Sheep (2022)

Penny Johnson Jerald, Seth MacFarlane, Jessica Szohr, Adrianne Palicki, J. Lee, Mark Jackson, and John Lamarr in Electric Sheep (2022)

Charlize Theron, Liam Neeson, and Seth MacFarlane in A Million Ways to Die in the West (2014)