Cousin of Amy McCarthy, Lynette McCarthy, Joanne McCarthy and most famously, Jenny McCarthy, on whose show, The Jenny McCarthy Show (1997), Melissa made her on-screen debut in 1997.
Is close friends with her former Samantha Who? (2007) co-star Christina Applegate.
Returned to work 3 months after giving birth to her daughter Vivian to begin filming the 1st season of Samantha Who? (2007).
Returned to work 4 months after giving birth to her daughter Georgette to begin filming the 1st season of Mike & Molly (2010).
Alumni of the improvisational comedy troupe The Groundlings, where she was a member for nearly 10 years.
Is good friends with Octavia Spencer.
Mother, with husband Ben Falcone, of daughters Vivian Falcone (b. May 5, 2007) and Georgette Falcone (b. March 22, 2010).
Grew up on a farm and loved playing tennis.
Attended and graduated from St. Francis Academy (now Joliet Catholic Academy) in Joliet, Illinois.
Received a star on the Hollywood Walk of Fame at 6927 Hollywood Boulevard in Hollywood, California on May 19, 2015.
Parents are Michael and Sandra McCarthy.
Her paternal grandparents, Michael McCarthy (born Michael Carty) and Ann O'Reilly, were immigrants, both of Irish origin, with roots in County Longford and County Armagh. Her mother is of Irish, German, and English ancestry.
Her favorite film is Planes, Trains & Automobiles (1987).
Was the second-highest paid actress in 2016, behind Jennifer Lawrence.
Fourth highest-paid actress of 2017 with $18 million.
Worked as a costumer for a dance company in Colorado.
Before she became famous, she was hired as an extra in 1996 for The Preacher's Wife (1996). On the day of filming, which took place inside a church, McCarthy was wearing a yellow sweater which was provided by the production. Director Penny Marshall, who was staging the background via monitors, noticed the sweater, which she found distracting as it was the same color yellow worn by the choir in the scene. Marshall took to the stage and asked the extra to leave due to the wardrobe clash. It wasn't until several years later that Marshall found out that the extra was a then-unknown Melissa McCarthy. Marshall relays the story in a 2013 interview with the Archive of American Television.
After her first audition, she was told that she was "not the neighbor type".
Nominated for the 2019 Golden Globe Award in the Best Performance by an Actress in a Motion Picture - Drama category for her role as Lee Israel in Can You Ever Forgive Me? (2018), but lost to Glenn Close for The Wife (2017).
In January 2019, she was nominated for both Golden Raspberry Awards and Academy Awards in 24 hours.
Nominated for a 2019 Academy Award in the Best Actress in a leading Role category for her role as Lee Israel in Can You Ever Forgive Me? (2018) but lost to Olivia Colman for The Favourite (2018).
Fan of Billie Eilish whose mother Maggie Baird was her first improv teacher at The Groundlings.