- No relation to fellow actor Dylan McDermott, despite a popular misconception.
- Dean gave his daughter Stella McDermott the middle name, Doreen in honor of his late mother, while his wife Tori Spelling gave their son Liam McDermott the middle name, Aaron after her father, the late Aaron Spelling, Hattie McDermott, the middle name of Margaret, after her childhood nanny and Finn McDermott, the middle name of Davey, after Tori's middle name.
- Dean has five children with his wife, Tori Spelling. Liam McDermott (aka Liam Aaron McDermott), born March 13, 2007, weighing 6 lbs. 6 oz.; Stella McDermott (aka Stella Doreen McDermott), born June 9, 2008, weighing 6 lbs. 8 oz.; Hattie McDermott (aka Hattie Margaret McDermott), born October 10, 2011, weighing 6 lbs. 14 oz.; Finn McDermott (aka Finn Davey McDermott), born August 30, 2012, weighing 6 lbs. 6 oz., and and Beau Dean McDermott, born March 2, 2017 weighing 5 lbs., 12 oz, at Cedars-Sinai Medical Center, Los Angeles, California, all by C-section (Liam was an emergency C-section).
- Eloped with Tori Spelling to a private island in Fiji on 7 May 2006.
- Son-in-law of the late Aaron Spelling and Candy Spelling.
- Brother-in-law of Randy Spelling.
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