- In 2008, co-wrote a pilot with Louis C.K. for CBS but it was not picked up.
- Father was American and mother is English.
- As a U.S citizen, in January 2020 registered as a British citizen (possible due to her mother being British), so now is a dual US and British national.
- Her father was of Russian Jewish and Ukrainian Jewish descent. Her mother, originally an Episcopalian, converted to Judaism.
- Formerly a close friend of Louis CK who appeared often on his show "Louie" and wrote the first 2 seasons of her series "Better Things" with him. After news of CK's sexual harrassment emerged in November 2017, Adlon cut ties with him and fired her former manager (who had also managed CK). In the runup to Season 3 of "Better Things", Adlon confirmed in a profile in The New Yorker that she had not any contact with CK in a very long time, and that she was trying to not mention or reference him during the show's production.
- Daughter of Don Segall.
- Nominated for the 2018 Emmy Award in the Lead Actress in a Comedy Series category for her role as Sam Fox in Better Things (2016), but lost to Rachel Brosnahan from The Marvelous Mrs. Maisel (2017).
- She splits her time between Manhattan, New York and Los Angeles, California.
- Older sister of Penina Segall.
- Former daughter-in-law of Percy Adlon and Eleonore Adlon.
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