Jon Cryer and Amber Tamblyn in Two and a Half Men (2003)

Alexis Bledel, Blake Lively, Amber Tamblyn, and America Ferrera in The Sisterhood of the Traveling Pants (2005)

Alexis Bledel, Blake Lively, Amber Tamblyn, and America Ferrera in The Sisterhood of the Traveling Pants 2 (2008)

Amber Tamblyn in The Sisterhood of the Traveling Pants (2005)

Alexis Bledel, Ken Kwapis, Blake Lively, Amber Tamblyn, and America Ferrera in The Sisterhood of the Traveling Pants (2005)

Amber Tamblyn and America Ferrera in The Sisterhood of the Traveling Pants (2005)

Parker Posey, Rachel Dratch, Amy Poehler, and Amber Tamblyn in Spring Breakdown (2009)

Rachael Bella and Amber Tamblyn in The Ring (2002)

Hugh Laurie and Amber Tamblyn in House (2004)

Jesse Spencer, Amber Tamblyn, and Olivia Wilde in House (2004)

Amber Tamblyn and Olivia Wilde in House (2004)

Amber Tamblyn and Lisa Barlow in Watch What Happens Live with Andy Cohen (2009)

James Franco, Kate Mara, and Amber Tamblyn in 127 Hours (2010)

Amber Tamblyn in Buffy the Vampire Slayer (1997)

Bob Odenkirk and Amber Tamblyn in Girlfriend's Day (2017)

Amber Tamblyn in The Increasingly Poor Decisions of Todd Margaret (2009)

Jon Cryer, Ashton Kutcher, Amber Tamblyn, and Kelly Sry in Two and a Half Men (2003)

Clark Duke and Amber Tamblyn in Two and a Half Men (2003)

Terry Kinney, Jeremy Renner, Amber Tamblyn, and Waris Ahluwalia in The Unusuals (2009)

Jeremy Renner and Amber Tamblyn in The Unusuals (2009)

Kuno Becker, Amber Tamblyn, and Madalyn Horcher in House (2004)

Amber Tamblyn in Two and a Half Men (2003)

Carl Reiner, Amber Tamblyn, and Holland Taylor in Two and a Half Men (2003)

Jon Cryer, Ashton Kutcher, and Amber Tamblyn in Two and a Half Men (2003)

Joe Mantegna, Mary Steenburgen, Jason Ritter, Amber Tamblyn, and Michael Welch in Joan of Arcadia (2003)

Amanda Bynes, Alexis Bledel, Hilary Duff, Blake Lively, Amber Tamblyn, and America Ferrera in What a Girl Wants (2003)

Arielle Kebbel, Amber Tamblyn, and Sarah Roemer in The Grudge 2 (2006)

Amber Tamblyn in Normal Adolescent Behavior (2007)