Mandy Moore and Milo Ventimiglia in This Is Us (2016)

Milo Ventimiglia and Parker Bates in This Is Us (2016)

Mandy Moore, Milo Ventimiglia, Lonnie Chavis, Parker Bates, and Mackenzie Hancsicsak in This Is Us (2016)

Mandy Moore, Milo Ventimiglia, Lonnie Chavis, and Parker Bates in This Is Us (2016)

Milo Ventimiglia and Liam Hemsworth in Land of Bad (2024)

Milo Ventimiglia and Rachel Brosnahan in Ethan... Esther... Chaim (2022)

Milo Ventimiglia in Ethan... Esther... Chaim (2022)

Alan Cumming and Milo Ventimiglia in Milo Ventimiglia & Alan Cumming (2023)

Kate Beckinsale and Milo Ventimiglia in The Late Late Show with James Corden (2015)

Milo Ventimiglia in How Milo Ventimiglia and "Heroes" Changed Everything (2019)

Milo Ventimiglia in Milo Ventimiglia (2019)

Milo Ventimiglia, Amanda Seyfried, Butler, and Ryan Kiera Armstrong in The Art of Racing in the Rain (2019)

Milo Ventimiglia and Parker in The Art of Racing in the Rain (2019)

Milo Ventimiglia and Butler in The Art of Racing in the Rain (2019)

Milo Ventimiglia, Amanda Seyfried, and Butler in The Art of Racing in the Rain (2019)

Conan O'Brien, Andy Richter, and Milo Ventimiglia in Conan (2010)

Milo Ventimiglia in American Dreams (2002)

Skeet Ulrich, Matt Dillon, Laurence Fishburne, Jean Reno, Milo Ventimiglia, Amaury Nolasco, and Columbus Short in Armored (2009)

Cristine Rose, Ali Larter, Jack Coleman, Greg Grunberg, Hayden Panettiere, Adrian Pasdar, Zachary Quinto, Sendhil Ramamurthy, Milo Ventimiglia, Masi Oka, Dania Ramirez, and James Kyson in Heroes (2006)

Lacey Chabert, Zoe Saldaña, and Milo Ventimiglia in Dirty Deeds (2005)

Adam Goldberg, Frankie Muniz, William Brent Bell, Sophia Bush, Jon Foster, McG, Wendell Pierce, Jimmi Simpson, Milo Ventimiglia, and Samaire Armstrong in Stay Alive (2006)