She started acting in 2002, and she has also worked in Music departments. It happened in an episode of The Last Man on Earth (2015), but her very 1st experience was in the movie Lie (2006), starring the Actor and Singer Alan Miller, featuring Miranda Cosgrove in the cast. By the way, Alan Miller is one of Matthew Daddario's favorite actors.

Her parents are lawyers. Her father, Richard C. Daddario, was a Federal Prosecutor in New York City for 13 years, before being named Head of the NYC Police Department's Anti-terrorism Bureau (in 2010).

Her father has is of 75% Italian and 25% Irish descent, while her mother has Hungarian, Slovak, German, and English ancestry.

When she was 16 years old, she got transferred from Brearley School to the Professional Children's School (in New York), so she could better focus on her acting skills.

Attended Marymount Manhattan College in NYC.

Older sister of the actors Matthew Daddario and Catharine Daddario.

Ranked #80 on Maxim's "Hot 100" of 2014 list.

She did voiceover work on "I Spy School Days" (a book of picture riddles).

Appeared tied up and gagged on screen in the movie Texas Chainsaw 3D (2013).