- Her low-pitched husky voice is a result of having baby colic, a condition of chronic crying as an infant. It lasted six months and resulted in the development of nodules. She has calluses on her vocal cords as an adult.
- She didn't know she had asthma until she had an asthma attack while filming Easy A (2010).
- Although she's known as a redhead, her natural hair color is blonde. It was Judd Apatow who suggested she change her hair color for Superbad (2007) and she liked it so much that she decided to keep it.
- She convinced her parents to let her move to Hollywood when she was age 15 by making a PowerPoint presentation aptly titled, Project Hollywood.
- Has matching bird tattoos with her mother, the birds referring to The Beatles' song, "Blackbird". Sir Paul McCartney drew the birds himself.
- Deleted her Twitter account @stonenobrien when someone hacked it. She has since sworn off social media.
- Started to use "Emma" as her professional name, because there was already an "Emily Stone" when she applied for her SAG card.
- Though it is her trademark, she doesn't like the sound of her voice, saying to E! Online "I still can't believe I sound like this.".
- Has played a love interest with Ryan Gosling three times. It could have been four, but they both had dropped out of the movie, Focus (2015), with Margot Robbie and Will Smith replacing them.
- Was in a relationship with actor Andrew Garfield from 2011 to October 2015.
- One of her dreams was to appear on Saturday Night Live (1975), which she achieved in 2010, in 2011, and again in 2016.
- Auditioned for the role of Claire Bennet in Heroes (2006), but lost out to Hayden Panettiere. She referred to this experience as "rock bottom".
- Highest paid actress of 2017 with $26 million.
- She was performing in Cabaret on Broadway when she was cast for her Academy Award winning role in La La Land (2016). Before her triumph the last time an actress won Leading Actress for a musical was Liza Minnelli for the movie version of Cabaret (1972).
- Was considered for the lead female role in 21 Jump Street (2012), but she had to drop out due to scheduling conflicts with The Amazing Spider-Man (2012).
- Prefers to be called Emily over Emma.
- When she was age 7, she fell off the parallel bars in gymnastics and broke both her arms.
- Her mother is a breast cancer survivor.
- Her family's surname was anglicized to "Stone" after immigrating to the United States.
- Has a daughter: Louise Jean McCary (b. March 13, 2021) with husband, Dave McCary.
- Her parents owned the Camelback Golf Course in Scottsdale, Arizona.
- Was an obsessive fan of the Spice Girls, Emma Bunton being her favorite.
- Is a big fan of the show iCarly (2007) and got to appear in one of its final episodes.
- Has a phobia of being lifted in the air, because she broke her arms after being lifted onto a high beam.
- Her favorite films are City Lights (1931), Harold and Maude (1971), Network (1976) and Manhattan (1979).
- Named as having the "Sexiest sense of humor" by Victoria's Secret What Is Sexy list (2012).
- She is of Swedish (paternal grandfather), German, as well as Welsh, Irish, English, Scottish, and Swiss-German, ancestry. Her family's surname was changed from Sten to Stone.
- The first name of "Wichita," her character in Zombieland (2009), is Krista. This is likely in homage to her mother, whose first name is also Krista.
- She got her start in acting at 11 years of age at the Valley Youth Theatre in Phoenix, AZ, where she starred in over 16 stage productions as well as performing the theatre's comedy improv troupe. Caylee Cowan was also acted at the Valley Youth Theatre.
- Is one of 8 actresses to have won an Academy Award for their performance in a musical. The others in chronological order are; Rita Moreno, Julie Andrews, Barbra Streisand, Liza Minnelli, Catherine Zeta-Jones, Jennifer Hudson and Anne Hathaway.
- She has appeared in five films that have been nominated for the Best Picture Oscar: The Help (2011), Birdman or (The Unexpected Virtue of Ignorance) (2014), La La Land (2016), The Favourite (2018) and Poor Things (2023). Birdman won in the category.
- Her middle name, Jean, was her grandmother's first name.
- Is a big fan of Marion Cotillard and revealed to French newspaper L'Express that she can't count the times that she reenacted the scenes from La Vie En Rose (2007) in her room.
- In elementary school, she started being called Emma after Emma Bunton because she's a huge fan of the Spice Girls & her hair color used to be blonde.
- Unexpectedly announced that she decided to pull out of her planned co-starring role with Alan Cumming--and forgo her Broadway debut--in the 2014 revival production of the musical "Cabaret". The Sally Bowles role ultimately went to Michelle Williams under the direction of Sam Mendes (2014). (June 2013)
- Returned to work 6 months after giving birth to her daughter Louise to begin filming Poor Things (2023).
- Attended Xavier College Preparatory in Phoenix, Arizona.
- In two of her films, Easy A (2010) and Crazy, Stupid, Love. (2011), Nathaniel Hawthorne's "The Scarlet Letter" is discussed.
- Shares with her The Help (2011) co-star Bryce Dallas Howard the role of "Gwen Stacy".
- Ranked #5 on Askmen's list of the top 99 "most desirable" women for 2013.
- Has a younger brother named Spencer Stone.
- Merited a place in TIME magazine's "The 100 Most Influential People" issue with an homage - "The Emerging Icon" - written by friend Brie Larson. (May 2017)
- Announced her engagement to Saturday Night Live writer/director Dave McCary after 2 years of dating on December 4, 2019.
- Both she and her Aloha (2015) co-star, Rachel McAdams, had starred in romance movies with Ryan Gosling. In their films with Gosling, the two actresses do a love scene with the actor in the home his character lives in, after having coming in out of the rain.
- Was considered for the role of "Cinderella" in the Disney live action musical, "Into The Woods", but said no. She was also considered for the role of "Debora" in the 2017 action movie, Baby Driver (2017), but said no due to her filming La La Land (2016), The role of "Debora" went to Lily James, who played "Cinderella" in the 2015 live action Disney remake, Cinderella (2015), as the title character.
- Was considered one of the 55 faces of the future by Nylon Magazine Young Hollywood Issue.
- She was originally cast as "Amber" in Sucker Punch (2011), but had to drop out due to scheduling conflicts. The role later went to Jamie Chung.
- Her father Jeff is a contractor and her mother Krista is a homemaker.
- Was one of the choices to play Elizabeth Bennett in the 2016 horror action movie, Pride and Prejudice and Zombies (2016).
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