After completing a qualification as an enrolled nurse at TAFE, Vidis became a nurse in 2006. To earn extra money, she began waitressing on weekends, and she then went into topless waitressing, nude waitressing and eventually strip shows. Within a few months, she quit her job as a nurse. In addition to her strip shows, she also started modeling part time for Australian men's magazines. In 2008, Vidis was interviewed by 60 Minutes for an investigative piece regarding the sexualisation of Australian youth in recent years. Also included in the interview was Jodie Moore and Moore's mother. After being seen on the cover of Australian People Magazine, she was asked to audition for a new American reality TV show to be produced on behalf of Playboy TV. After receiving that role, she moved to Los Angeles, where she started making adult films. The TV show, entitled Kiki's American Adventure, was her breakout role to get into the adult industry. After being in the USA, Vidis returned to Australia, where she continued to model and make feature appearances. Vidis is notable for being the only stripper in Australia to perform anal fisting in her strip shows. Kiki Vidis regularly travels back to the USA to make more films. Since 2008, Vidis has made at least 50 adult films. Vidis' younger sister Layla was also involved in the adult industry and did topless waitressing as well as nude modeling. The two sisters have done nude photo shoots together. Vidis' mother, Mia, was also involved in the adult industry and had done nude modeling, including some photo shoots with Kiki as well as performing mother/daughter strip shows with Kiki at New Zealand's Erotica Expo. Vidis is the founder and manager of Kiki's Kasting, which is Australia's only adult industry casting agency. Kiki Vidis has a weekly column in Australian People Magazine known as "Kiki's Korner".