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In Surprising Plot-Twist, "Brothers & Sisters" Takes on HIV/AIDS

Warning: This article contains spoilers for the "On the Road Again" episode of Brothers & Sisters.

The death of Robert McCallister (Rob Lowe) in Sunday night's season finale of Brothers & Sisters may have been one of the worst-kept secrets in television history.

But the same episode, "On the Road Again," contained another a pivotal plot-twist that caught many viewers by complete surprise.

Uncle Saul, played by Ron Rifkin, is HIV-positive.

He joins an extremely small number of gay characters on scripted American television who have ever been identified as HIV-positive. The last such character, at least in such a high-profile TV project, may have been the character of Vince Taylor (Anthony Azizi) on the 2005-2006 series Commander-in-Chief.

Other regular gay or bisexual HIV-positive characters in TV history include Lee Campbell on The Best Years (a Canadian import that aired on The N in 2007), and several characters on the Showtime series Queer as Folk.

See full article on The Backlot