Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "fatal-disease"

1. Dallas Buyers Club (2013)

R | 117 min | Biography, Drama

In 1985 Dallas, electrician and hustler Ron Woodroof works around the system to help AIDS patients get the medication they need after he is diagnosed with the disease.

Director: Jean-Marc Vallée | Stars: Matthew McConaughey, Jennifer Garner, Jared Leto, Steve Zahn

Votes: 518,773 | Gross: $27.30M

2. Philadelphia (1993)

PG-13 | 125 min | Drama

When a man with HIV is fired by his law firm because of his condition, he hires a homophobic small time lawyer as the only willing advocate for a wrongful dismissal suit.

Director: Jonathan Demme | Stars: Tom Hanks, Denzel Washington, Roberta Maxwell, Buzz Kilman

Votes: 257,817 | Gross: $77.32M

3. Revolver (2005)

R | 111 min | Action, Crime, Drama

Gambler Jake Green enters into a game with potentially deadly consequences.

Director: Guy Ritchie | Stars: Jason Statham, Ray Liotta, André 3000, Vincent Pastore

Votes: 102,598 | Gross: $0.08M

4. Last Holiday (2006)

PG-13 | 112 min | Comedy, Drama, Romance

Upon learning of a terminal illness, a shy woman decides to sell all her possessions and live it up at a posh Central European hotel.

Director: Wayne Wang | Stars: Queen Latifah, LL Cool J, Timothy Hutton, Giancarlo Esposito

Votes: 36,217 | Gross: $38.36M

5. Total Eclipse (1995)

R | 111 min | Biography, Drama, Romance

Young, wild poet Arthur Rimbaud and his mentor Paul Verlaine engage in a fierce, forbidden romance while feeling the effects of a hellish artistic lifestyle.

Director: Agnieszka Holland | Stars: Leonardo DiCaprio, David Thewlis, Romane Bohringer, Dominique Blanc

Votes: 16,762 | Gross: $0.34M

6. The Mighty (1998)

PG-13 | 100 min | Comedy, Drama

Two young boys are social outcasts in their community due to their disabilities and broken home lives. When they are paired together, they form a bond over their shared circumstances.

Director: Peter Chelsom | Stars: Kieran Culkin, Elden Henson, Sharon Stone, Harry Dean Stanton

Votes: 13,892 | Gross: $2.64M

7. The Andromeda Strain (2008)

44 min | Drama, Mystery, Sci-Fi

A crack team of top scientists work feverishly in a secret, state-of-the-art laboratory to discover what has killed the citizens of a small town and learn how this deadly contagion can be stopped.

Stars: Benjamin Bratt, Christa Miller, Ricky Schroder, Louis Ferreira

Votes: 14,607

8. You're Not You (2014)

R | 102 min | Drama

A drama centered on a classical pianist who has been diagnosed with ALS and the brash college student who becomes her caregiver.

Director: George C. Wolfe | Stars: Hilary Swank, Emmy Rossum, Josh Duhamel, Stephanie Beatriz

Votes: 26,810

9. Playing by Heart (1998)

R | 121 min | Comedy, Drama, Romance

Eleven articulate people work through affairs of the heart in Los Angeles.

Director: Willard Carroll | Stars: Gillian Anderson, Ellen Burstyn, Sean Connery, Anthony Edwards

Votes: 20,281 | Gross: $3.96M

10. The Shoes of the Fisherman (I) (1968)

G | 162 min | Drama

After spending decades in a Siberian Gulag labor camp, Roman Catholic priest Kiril Lakota is set free by Russian leader Piotr Ilyich Kamenev at the height of the Cold War.

Director: Michael Anderson | Stars: Anthony Quinn, Laurence Olivier, Oskar Werner, David Janssen

Votes: 4,148

11. Letter from an Unknown Woman (1948)

Not Rated | 87 min | Drama, Romance

A pianist about to flee from a duel receives a letter from a woman he cannot remember, who may hold the key to his downfall.

Director: Max Ophüls | Stars: Joan Fontaine, Louis Jourdan, Mady Christians, Marcel Journet

Votes: 13,630

12. The Dark Side of the Sun (1988)

R | 101 min | Drama, Romance

Traveling in search of a cure for a rare skin disease, a man finds freedom and love along the way.

Director: Bozidar 'Bota' Nikolic | Stars: Guy Boyd, Brad Pitt, Cheryl Pollak, Constantin Nitchoff

Votes: 3,734

13. The Secret (2006 Video)

PG | 90 min | Documentary

Interviews with self-proclaimed authors, philosophers and scientists, with an in-depth discussion of visualizing your goals. The audience is shown how they can learn and use 'The Secret' in their everyday lives.

Director: Drew Heriot | Stars: Bob Proctor, Joe Vitale, John Assaraf, Loral Langemeier

Votes: 14,042

14. Tales of Terror (1962)

Not Rated | 89 min | Comedy, Horror, Mystery

Three tales of terror involve a grieving widower and the daughter he abandoned; a drunkard and his wife's black cat; and a hypnotist who prolongs the moment of a man's death.

Director: Roger Corman | Stars: Vincent Price, Maggie Pierce, Leona Gage, Peter Lorre

Votes: 8,364

15. Man of a Thousand Faces (1957)

Approved | 122 min | Biography, Drama

The life and career of vaudevillian and silent-screen horror star Lon Chaney, including his contentious relationship with his neurotic wife and his premature death.

Director: Joseph Pevney | Stars: James Cagney, Dorothy Malone, Jane Greer, Marjorie Rambeau

Votes: 2,958

16. Bigger Than Life (1956)

Not Rated | 95 min | Drama

A seriously-ill schoolteacher becomes dependent on a "miracle" drug that begins to affect his sanity.

Director: Nicholas Ray | Stars: James Mason, Barbara Rush, Walter Matthau, Robert F. Simon

Votes: 8,141

17. Mary and Martha (2013 TV Movie)

TV-PG | 95 min | Drama

Two mothers lose their sons to malaria.

Director: Phillip Noyce | Stars: Hilary Swank, Brenda Blethyn, Sam Claflin, Frank Grillo

Votes: 3,614

18. How to Survive a Plague (2012)

Not Rated | 110 min | Documentary, History, News

The story of two coalitions -- ACT UP and TAG (Treatment Action Group) -- whose activism and innovation turned AIDS from a death sentence into a manageable condition.

Director: David France | Stars: Peter Staley, Larry Kramer, Iris Long, Bob Rafsky

Votes: 4,354 | Gross: $0.13M

19. Emmett's Mark (2002)

R | 104 min | Crime, Drama, Romance

In order to avoid the debilitating effects of a terminal illness, a young detective orders a hit on himself.

Director: Keith Snyder | Stars: Scott Wolf, Tim Roth, Gabriel Byrne, Greg Wood

Votes: 2,011

20. What Makes a Family (2001 TV Movie)

TV-14 | 91 min | Drama

When an artificially-inseminated woman dies, her partner must fight to regain custody of their child.

Director: Maggie Greenwald | Stars: Brooke Shields, Cherry Jones, Anne Meara, Al Waxman

Votes: 814

21. Jacqueline Susann's Valley of the Dolls (1981)

233 min | Drama

Updated version of the Jacqueline Susann best selling 1960's novel shows the lives of three very different women who come to New York City to achieve fame and fortune in show business and ... See full summary »

Stars: Catherine Hicks, Lisa Hartman, Veronica Hamel, David Birney

Votes: 204

22. The Big Bluff (1955)

Approved | 71 min | Crime, Drama, Film-Noir

When a scheming fortune hunter finds his rich wife is not going to die as expected, he and his lover make other plans to get her millions.

Director: W. Lee Wilder | Stars: John Bromfield, Martha Vickers, Robert Hutton, Rosemarie Stack

Votes: 607

23. Hustler Squad (1975)

R | 98 min | Action, Drama, War

World War II: Allied Command learns that in 60 days three Japanese generals and an admiral party at a bordello on a tiny Philippine island. It's fortified and hard to attack, so a creative,... See full summary »

Director: Cesar Gallardo | Stars: John Ericson, Karen Ericson, Crystin Sinclaire, Nory Wright

Votes: 550

24. We Were Here (I) (2011)

Not Rated | 90 min | Documentary, Biography, History

A deep and reflective look at the arrival and impact of AIDS in San Francisco and how individuals rose to the occasion during the first years of this unimaginable crisis.

Directors: David Weissman, Bill Weber | Stars: Ed Wolf, Daniel Goldstein, Guy Clark, Eileen Glutzer

Votes: 2,279

25. She Lives! (1973 TV Movie)

74 min | Drama

A young couple searches for the cure for the girl's terminal illness.

Director: Stuart Hagmann | Stars: Desi Arnaz Jr., Season Hubley, Anthony Zerbe, Michael Margotta

Votes: 138

26. You Shine in the Moonlight (2019)

101 min | Drama, Romance

Takuya Okada is a high school student. He visits his classmate Mamizu Watarase in the hospital. Mamizu suffers from the mysterious ailment "Luminescence disease." People who have the ... See full summary »

Director: Shô Tsukikawa | Stars: Takumi Kitamura, Mei Nagano, Kyoko Hasegawa, Tomoko Ikuta

Votes: 343

27. Yesterday Once More (2004)

Not Rated | 99 min | Comedy, Crime, Romance

Romance blossoms again for a divorced jewel-thief couple as they try to rekindle the love they once had for each.

Director: Johnnie To | Stars: Andy Lau, Sammi Cheng, Jenny Hu, Carl Ng

Votes: 993

28. The Second Wife (1967)

105 min | Drama

A corrupt mayor, who rules the village's people with power and injustice, forces another poor man's wife secretly to marry him in order to have a child.

Director: Salah Abouseif | Stars: Suad Husni, Shukri Sarhan, Sanaa Gameel, Salah Mansour

Votes: 957

29. Miss Susie Slagle's (1946)

Passed | 88 min | Drama

A student nurse falls in love with a young intern in 1910 Baltimore, but tragedy ensues when he contracts a fatal disease.

Director: John Berry | Stars: Veronica Lake, Sonny Tufts, Joan Caulfield, Ray Collins

Votes: 155

30. The Directive (2019)

113 min | Action, Comedy, Sci-Fi

One year after a catastrophic pandemic wipes out most of humanity, a lone survivor embarks on a journey to find Safe Zone 57 with the help of a broken robot.

Director: Alexander Raye Pimentel | Stars: Paul Askedall, Nicholas Winand, Kyle Abraham, Scott Thompson

Votes: 1,315

31. The Moon Child (2011)

110 min | Drama

Romain, 13, has suffered from a rare genetic deficiency since early childhood, which prevents him from exposing himself to daylight. Romain remains very combative thanks to the support of David, his doctor.

Director: Delphine Gleize | Stars: Vincent Lindon, Emmanuelle Devos, Quentin Challal, Caroline Proust

Votes: 260

32. Zonen (1996)

336 min | Drama, Mystery, Thriller

The Military evacuates a zone in the Lapland mountains, under the pretext that there is an ongoing exercise. The district doctor gets suspicious when one of his patients, who lived inside ... See full summary »

Stars: Jacob Nordenson, Peter Haber, Thomas Hanzon, Sissela Kyle

Votes: 188

33. Blueprint (1992)

190 min | Mystery, Thriller

A chilling thriller in the shadow of a nuclear power industry and cynical research around human life and death. There power and money means everything, and life nothing. Somebody must stand... See full summary »

Stars: Åsa Karlin, Gerhard Hoberstorfer, Peter Haber, Torsten Näslund

Votes: 70

34. Why She Smiles (2021)

TV-G | 40 min | Documentary, Short, Biography

Why She Smiles is the true, inspirational story of 34-year old Jamie Sorum, who is battling Huntington's Disease. Huntington's Disease is a rare, fatal neurological disease with symptoms ... See full summary »

Director: Caroline Sims | Stars: Jamie Sorum, Pat Sorum, Jim Sorum, Daniel Jeffrey

Votes: 32

35. XP (2003)

11 min | Short

A young boy with a rare skin disease is safe to only to go outdoors in the dark of night, while he is eager to do the contrary despite the risk.

Director: David Barba | Stars: Blake Coelho, Roberto Garcia, Jennifer Scott

Votes: 5

36. The Genius and the Boys (2009 TV Movie)

Documentary, Biography

The documentary investigates late American Nobel laureate Carleton Gajdusek's enigmatic discoveries. Gajdusek discovered mad cow disease on Papua New Guinea in the fifties, as well as ... See full summary »

Director: Bosse Lindquist | Stars: Michael Alpers, Warwick Anderson, Sena Anua, Carleton Gajdusek

Votes: 65

37. Vintage Model (1992)

95 min | Drama, Family, Romance

Carmen is fond of astrology and conducts her own program of romantic advice on the radio. However, she lives trapped in her own time and in her past.

Director: Raúl Araiza | Stars: Silvia Pinal, Alonso Echánove, Daniela Durán, Stephanie Salas

Votes: 52

38. Driven to Help (2022 TV Movie)

46 min | Documentary

Imagine a disease so rare there's no cure. Austin Crawford was diagnosed with MSA or Multiple System Atrophy. As his health fades we find Austin building a hot rod from his wheelchair and sharing his story to his followers on Tiktok.

Director: Phil Gioja | Star: Austin Crawford

Votes: 9

39. Stars (2005)

10 min | Animation, Short, Drama

An experimental animated film centers on Sophie who learns she has a rare fatal neuron disease. As her condition deteriorates she experiences sensory hallucinations up until her final days ... See full summary »

Director: Eoghan Kidney | Stars: Ruth Negga, Domhnall Gleeson, Mal Whyte, Maureen O'Connell

Votes: 43

40. Sang yat fai lok (2007)

107 min | Romance

Rene Liu successfully delivers the complex role of Mi, who chooses to remain single rather than risking the slightest chance of being dumped. She loves her friend Nan (Louis Koo) more than ... See full synopsis »

Director: Jingle Ma | Stars: Louis Koo, Rene Liu, Lawrence Chou, Bowie Tsang

Votes: 388

41. The Dying Detective (1921)

28 min | Drama, Crime, Mystery

The great detective Sherlock Holmes, near death after having contracted a rare and usually fatal Asiatic disease, is determined to solve one last murder case before he passes on.

Director: Maurice Elvey | Stars: Eille Norwood, Hubert Willis, Cecil Humphreys, Joseph R. Tozer

Votes: 53

42. Konfrontace (1971 TV Movie)

Crime, Drama

A wealthy New York business executive receives an anonymous letter stating that his beautiful wife, who lives in the whirlwind of everyday pleasure in a high-powered company, is not the ... See full summary »

Director: Jirí Sequens | Stars: Josef Abrhám, Josef Bek, Otakar Brousek, Slávka Budínová

Votes: 17

43. Thrown Over: Burial at Sea (2014 Video)

4 min | Documentary, Short, History

Exploring the history of how disease and illness shaped sea voyages 'Thrown Over' toured Australia in 2026-17 as part of the Rough Medicine: Life and Death in the Age of Sail travelling exhibition.

Director: Ashley Starkey

44. Legenda o lyubvi (1969 TV Movie)

42 min | Drama, Music

Add a Plot

Directors: Yelena Macheret, Yuri Grigorovich | Stars: Inna Zubkovskaya, Marina Kondrateva, Nikita Dolgushin, Konstantin Nazarov

45. La noche del fin del mundo (2008 TV Movie)

120 min | Documentary, History

Exactly to the 1:23:45 AM, in the night of Friday 26 April, 1986, happened the worst nuclear disaster of all 20th Century: Chernobyl. Journalist Iker Jiménez, host and creator of the ... See full summary »

Directors: Iker Jiménez, Sergio Fernández de Pinedo, Manuel Romo, Álvaro Sanmartín, Carmen Porter | Stars: Iker Jiménez, Carmen Porter, Anna Korolevskaya, Ricardo García

Votes: 50

46. Sophie's Search for a Cure (2007)

64 min | Documentary

A documentary video about one woman's personal journey with Multiple System Atrophy. "Sophie's Search for a Cure" chronicles one woman's struggle with an untreatable, fatal ... See full summary »

Director: Jim Likowski | Stars: Adam Dohm, Deb Dohm, Eric Dohm, Sophie Dohm

47. Cancer in Two Voices (1994)

43 min | Documentary, Short, Romance

A lesbian couple's eight-year relationship is put under strain when Barbara is diagnosed with breast cancer. Barbara is told she has three years to live, and so she and Sandy document their lives with courage and frankness.

Director: Lucy Massie Phenix | Stars: Sandra Butler, Barbara Rosenblum

48. Future Medicine & the Curse of Immortality (2017 Video)

7 min | Short, Talk-Show

Dave Cullen discusses the problems that may come with us halting the aging process.

Stars: Dave Cullen, Karl Martin, Arjun Bansal

49. Star Trek: Enterprise (2001–2005)
Episode: Stigma (2003)

TV-PG | 43 min | Action, Adventure, Drama

T'Pol is diagnosed with a possibly fatal neurological disease as a result of a mind meld. Meanwhile, one of Phlox's wives visits Enterprise and becomes very interested in Trip.

Director: David Livingston | Stars: Scott Bakula, John Billingsley, Jolene Blalock, Dominic Keating

Votes: 1,735

50. Kraft Suspense Theatre (1963–1965)
Episode: Rapture at Two-Forty (1965)

TV-PG | 60 min | Crime, Drama, Mystery

When Paul Bryan, a high-powered lawyer, is diagnosed with an incurable disease, he decides to spend his last days living the high life on the French Riviera.

Director: William A. Graham | Stars: Ben Gazzara, Michael Rennie, Katherine Crawford, Antoinette Bower

Votes: 31