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- A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career at a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him yet.
- In Star Trek: Section 31, Emperor Philippa Georgiou joins a secret division of Starfleet tasked with protecting the United Federation of Planets, and must face the sins of her past.
- An average 28-year-old man who gains the ability to use the full extent of his brain's capabilities is hired by the F.B.I. as a consultant.
- A look at the professional and personal lives of some of the military's brightest legal minds in the courtroom, where each attorney is trained as a prosecutor, a defense lawyer, an investigator - and a Marine.
- When a Marine is accused of helping a terrorist escape from Guantanamo Bay, Abe and Harper believe that they have an open-and-shut case until they are mysteriously denied access to key evidence without explanation. Also, Trey and Maya attempt to get Rami reassigned back to their office.
- Abe and Harper's investigation into the accidental overdose of a Marine takes a turn when they can't find any fingerprints - even the deceased's - on the pill bottle, leading them to believe he was murdered. Also, Abe receives a warning about testifying in a lawsuit against the Corps, and Maya is concerned that her brother does not have his mental illness under control.
- Abe's colleagues must defend - and reluctantly prosecute - him when he is arrested and court-martialed for mutiny in regard to a 2010 mission in Afghanistan where he was one of the only survivors.
- While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline; Moriarty plots his next move.
- When Sasha discovers a link between her current patient, and a cadaver she dissected during medical school, the team traces the case to Amish country.
- Watson and the fellows treat a comic who collapsed at an open mic night; the team becomes concerned when Watson himself collapses and suffers another traumatic brain injury.
- Watson risks his career to treat a sickle cell patient with an unorthodox surgery. Meanwhile, Ingrid attempts to get her sister admitted to her spinal project.
- Stephens musters the courage to ask Watson to help him when his camgirl suddenly collapses during a video call; the team must act quickly to locate her before it's too late; Watson grapples with guilt over Sherlock's death.
- Watson runs into an old friend of Sherlock Holmes when her son Angus is admitted to UHOP for temporary paralysis; the fellows help Watson after he grows fond of Angus, pursuing various leads to find a cure to his illness.
- Ingrid tests her experimental paralysis treatment on her sister Gigi. After she starts exhibiting side effects, the team gets involved. Meanwhile, Mary and John bond following a tragedy.
- The clinic's latest patient, who is under treatment for Alien Hand Syndrome, comes under suspicion of fatally pushing his brother in front of a bus. Watson must determine if he is guilty or innocent.
- Watson confronts a past trauma from his days in the military when an Army friend's wife reaches out for help, concerned her husband is having a psychotic break. Meanwhile, Moriarty has one final task for Shinwell.
- The team scrambles for answers when both of the Crofts fall badly ill with a mysterious ailment.
- The team must make an awful decision when it seems that only one of the twins can be saved. Meanwhile, Shinwell desperately races to help, and Watson finally confronts Moriarty.
- Brian Finch develops superhuman abilities after taking a mysterious drug called NZT, which finds him landing on the FBI's radar as he works to clear his name of an NZT-related murder.
- Brian learns a shocking secret about Rebecca's late father and accidentally meddles in her personal life while learning self-defense from her secret boyfriend, FBI Agent Casey Rooks.
- Brian risks his new FBI job when he disobeys orders to stay out of the investigation into a renowned journalist's murder.
- Brian helps Agents Harris and Boyle investigate the murder of a retired FBI agent and is shocked to find a link to the elusive head of a notorious drug cartel. Also, Brian reconnects with an old flame.
- Brian's loyalty to the FBI is tested when Sands demands he steal the FBI's secret files on NZT; Rebecca is emotionally conflicted when she learns what her estranged father left her following his death.