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After being kicked out of his home, a poor troubled youth, is taken in by a public defender and his family where he becomes embroiled in the lives of the wealthy, upper-class neighborhood of Newport Beach, Orange County in California.

CSI spin off which follows an elite group of Crime Scene Investigators (CSI's) from the Miami-Dade Police Department (MDPD), who use advanced forensic science and methods to solve complex crimes in cross-cultural Miami, Florida.

An environmental lawyer is poisoned with a radioactive isotope and has only one week left to help the CSI team find her murderer.

A drugs transport to incineration is attacked by a well-armed gang, but a woman shouting for help for her baby rather distracts Horatio and Speed, whose gun is jammed, but a bullet-proof vest saves his life. Only SWAT sergeant Hollis is killed, but as ballistics later establishes from a distant spot. Horatio finds the woman isn't the baby's mother, she was hired by a drugs gang. CSI is suspected of tipping them off, especially after Calleigh tests positive for cocaine, but Horatio traces that to a nearby spot suitable for the sniper. The fiends even left one of their own, badly wounded Lester Cassidy, behind to die in Paul Tomassi's workshop after consulting suspended MD Guillermo Santoyo.

A prostitute is found dead and a tourist is killed in a rental car.

A man's torso is found inside a shark.

When Ryan's brother, Trey, gets out of jail and gives Ryan a call, the Cohens give him a warm welcome. Though, Ryan knows nothing good can come from it. Zach returns from his trip to Italy and gives some news that he has a new girlfriend which makes Summer curious and Seth is not really sure what to think. Meanwhile, after Julie admits her naked mistake to Kirsten, they both agree to get Caleb in on it for more help, unaware that Caleb as always, has a hidden agenda. Also, the Newport Living magazine is officially launched, but Julie's blackmailer, Lance, makes an appearance after Caleb had stiffed him for his blackmail money.

On Trey's 21st birthday, Marissa, anxious to help Trey and Ryan forge a relationship, throws a birthday party for Trey at the Cooper-Nichol mansion that turns out to be a rumble when one girl nearly drowns from a drug OD. Meanwhile, Seth is left in hot water by both Summer and Zach. Sandy wants to continue his friendship with Carter, leaving a confused Kirsten. Also, a distraught Julie shares some memories with her blackmailer Lance, and in the process learns a few things and gains a few ideas about the future of her marriage to Caleb.

Seth and Zach declare war when they compete against each other for Summer's affections. Meanwhile, Marissa is still reeling from being nearly raped by Trey, and refuses to confide in Ryan about the incident. Sandy confronts Kirsten when her drinking problem becomes very apparent. Also, Caleb hands divorce papers to Julie.

When the Gaming Commission receives what it considers too many complaints on Ed, the board forces him to attend Anger Management. Mike considers asking for a loan from Ed in order to buy his new condo. Danny searches for an employee who is in so much need of money that he's willing to gamble with his life. Dalinda feels the need to do something with her life, and Sam gets jealous when one of her high profile big spenders comes to town and wants to take Mary to dinner instead of her.

A real estate developer is murdered, and the investigation uncovers a complex web of deceit involving his wife her two identical triplet sisters. But the apparently-murdered developer may have had a surprise of his own.

A nanny is murdered, and the suspects in her death include members of the family she was working for, her boss, her fellow nannies, and her ex-boyfriend.

A woman killed in a meth lab turns out to be an informant. CSI discovers that she was having a relationship with her married handler, and that she was also pregnant.

A man falls to his death from a skyscraper window, and the new M.E. is shot and killed at the scene. The crimes are soon connected to ammunition dealers, an ATF agent, and Horatio's son Kyle's new stepfather.

Calleigh could find herself in trouble after she is involved in an off-duty shooting. Meanwhile, the shooting leads detectives to a separate murder, which is connected to drug dealers.

A man is hanged from a gazebo during his ex-wife's divorce party, and the investigation reveals that he was leading a double life. Meanwhile, Horatio gets Kyle a job working with the medical examiner.

As Delko fights for his life once again, he flashes back to 1997 and the case that helped launch his career as a CSI.

A man desperate for justice creates a hostage situation at the Miami/Dade Police Department, and Horatio looks into his claims. One of the hostages is Jesse Cardoza, a former CSI who is returning to his old job.

A "cougar" is romantically connected to three victims who were electrocuted during a beach volleyball tournament, and the internal investigation into Calleigh and Delko comes to a conclusion.

An investment broker who stole millions is found dead in his plane, and the investigation reveals no shortage of people who wanted to kill him--but none of the money he stole.

The team investigates the scene of a fatal auto accident, but struggle to determine who was ultimately responsible and who was behind the wheel.

The team suspects that a company is killing its employees in order to collect on the insurance policies it put out on them, and a mysterious woman from Jesse's past returns.

The team finds the body of a dead census report taker in the trunk of a car, and the investigation takes a dangerous turn when it leads Wolfe and Boa Vista to a booby-trapped meth lab in an abandoned foreclosed home.

When America's sweetheart, Phoebe Nichols, bursts into flames during a concert, the CSIs expose the dark side of pop stardom.

A man is chopped in half, and the lab tries to tie the case to a Japanese mobster, who seeks custody of his biological son, who was adopted by the victim. Meanwhile, Natalia's hearing loss nearly makes her a victim during the investigation.