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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Detectives from NYPD's 15th Precinct investigate homicides within their precinct.
- An anthology series centered around America's most notorious crimes and criminals.
- An American grandson of the infamous scientist, struggling to prove that his grandfather was not as insane as people believe, is invited to Transylvania, where he discovers the process that reanimates a dead body.
- An ex-model and a smart-aleck detective manage a private detective agency.
- When his family goes away for the summer, a hitherto faithful husband with an overactive imagination is tempted by a beautiful neighbor.
- 1977–19871h 30mTV-GTV Episode6.7 (179)Stanley and Joyce Adams are nervous newlyweds. Leonora and Ernie Klopman meet widowed tailor Morris Beekman and happy spinster Mae Allen. Merrill demands that Julie seat Cleo Bagby at his table, but she's Gopher's girl and a stowaway.
- Maddie Hayes, an ex-fashion model, becomes the unlikely head of a detective agency led by a wise-cracking employee.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."