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Chicago's first responders unite in the wake of a catastrophic gas explosion and fire that threaten a city government building. Herrmann reluctantly shadows Pascal while Violet, Novak and Dr. Frost take charge of triage efforts on site.

An explosion at a hospital where Casey and Dawson are volunteering for a charity run sends Chicago into chaos.

A dangerous warehouse fire puts truck and squad at risk. Tensions rise for Dawson and Casey as Dawson's father overstays his welcome at their home. Mouch considers retirement.

The mattress factory fire spirals out of control. Truck and squad lay it on the line in hopes of getting the trapped victims out alive.

A fire at a boarding school shakes up Lt. Severide; Lt. Casey tries to help Dawson; Mills looks into his father's past.

Members of Firehouse 51 transport victims of a gas leak to nearby Chicago Med; an armed patient claiming to be carrying a deadly airborne disease forces Chicago Med into lockdown.

Severide watches over Detective Holloway's son while she testifies in court as part of an undercover operation, but he's left to deal with the situation due to an unexpected turn of events.

Firehouse 51 responds to the scene of a blaze that puts many lives in danger, including someone related to a Chicago police officer.

Firehouse 51 is taken over by local gangsters.

Casey takes drastic measures to help Kannell.

A raging fire consumes a 25-story apartment building complex, trapping victims on the top floors.

Severide and Kidd continue to investigate Benny's old arson case. Unexpected news leads Brett to ponder a big decision. All hell breaks loose.

McLeod continues to pressure Chief Boden, threatening to close Station 51, since he failed to retire as planned. "Mouch" steps up to pressure the union leader to preserve the station.

Mysterious threats begin to emerge throughout Chicago and the situation gets worse when news of a mass shooting brings Firehouse 51 into a dangerous scene.

Otis and Kidd respond to a call involving a residential fire only to head into danger when gunfire goes off in the house.

A deadly bacteria takes its toll on numerous victims around the city, leaving Chicago's finest first responders to work together alongside the CDC to resolve the dangerous situation; Severide suspects something bigger is happening.

Kelly pushes to get Peter on the Rescue Squad, while chewing out Casey for being around Darden's widow. A tragedy strikes the fire crew. There is a shooting at the firehouse. Herrmann tries to reconnect with his family.

All seems lost with firehouse 51 on the verge of closing its doors, thanks in no small part to Gail McLeod, but Chief Boden and the rest of the house refuse to allow themselves to sit by and let it happen. An emergency call to an apartment structure fire tests everyone's limits and puts the squad in harm's way. Meanwhile, Dawson receives some life-changing news and union president Greg Sullivan makes headlines, which has an immediate impact on Mouch.

Tensions run high when trucks from two firehouses collide and fingers are pointed towards Cruz for his driving.

The members of the firehouse spring into action when a helicopter explodes over a populated area.

Casey puts his life on the line and digs deeper into the shady dealings of Jack Nesbitt. With members of truck and squad at odds over Rice actions in the field, Chief Boden is left to figure out how to create unity in a divided house, while Severide comes to question his own judgment. A dangerous warehouse blaze quickly gets out of control and threatens members of firehouse 51, prompting Boden and Cruz to risk everything to save their own. Elsewhere, Dawson gets some life-changing news.

Casey is forced to take extreme measures when a forklift accidentally pierces a tank of acid, causing it to spill and putting a father and daughter in danger.

Louie's father throws a wrench into Casey and Dawson's family plans. Severide agrees to a bone marrow donation but a work accident throws everything into flux. Casey and Dawson try to find harmony at home. Meanwhile, Otis and Mouch decide to film a PSA encouraging people to join the Chicago Fire Department but hit a creative wall in the process.

Members of Firehouse 51 are split up and reassigned to various houses in Chicago by Chief Anderson.

Severide struggles to process his father's death; Brett thinks a teenage driver in a car accident is hiding something.