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After a subway tunnel caves in, Ruzek and Kidd help injured passengers and pursue a suspect. Archer and Frost amputate to save a life. Lenox shoulders CPD's expectations while trying to save a colleague.

The team fights to save the life of one of their own. Frost and Abrams butt heads with their patient. Asher helps a religious young woman with an ectopic pregnancy.

Maggie and Frost compete for lungs for a cystic fibrosis patient. Asher awaits surrogacy results. Ripley and Morris care for a billionaire's daughter with leukemia.

The hospital goes into lockdown mode when a man with a gun holds medical staff hostage. Goodwin is forced to make a tough decision. Dr. Rhodes begins to realize his time with his father is getting short.

Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well; an old friend from Frost's TV days shadows Maggie; Asher discovers an extremely rare condition in her patient's ultrasound.

Charles and Archer care for a heart recipient convinced his transplant rejects him. Lenox is off for a personal day. Hannah finds an ovarian mass in a pregnant patient.

Nurses mass sick-out creates hospital crisis. Archer and Frost compete over patient discharges. Charles struggles with treating a patient he doesn't trust.

An entire apartment complex is forced into quarantine when cases of the deadly virus turns into an epidemic. P.D. chases a lead that could point to a case of bio-terrorism and Will gets dangerously close to the suspect.

Asher treats a woman whose undiagnosed condition threatens the lives of both her and her unborn child; Goodwin receives a chilling message while battling the hospital higher-ups.

An army of surgeons prepares to separate conjoined twins; Asher reconnects with someone from her past; Archer treats a tyrannical boss with a heart problem.

Asher makes a tough call to save a life; Frost and Ripley treat a young boy with a snake bite; Archer gives Naomi a patient to handle on her own on her last day in the E.D.

Dr. Charles and Caroline set some major plans; Ava fights to keep her relationship with Connor. Agent Lee informs Will of news that may put his life in danger.

After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger. Will's proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.

An infection threatens Marcel's risky liver transplant. Maggie and Charles help a struggling burn unit nurse. Goodwin is forced to make a touch decision about Burt's future.

Ripley and Charles treat a high-risk prisoner who may have dementia. Archer and Sean clash when a resident from Margo's facility lands in the E.D. Marcel receives shocking news.

Gaffney gets a surprise visit from a National Accreditation Board of Hospitals representative; Asher and Naomi search for the cause of a young girl's infection; Lenox and Frost work together to save the victim of an accidental shooting.

The doctors and nurses of Chicago Med brace for an influx of patients when a multi-vehicle accident during a blizzard puts the hospital in scramble mode.

Choi and Halstead argue over how to treat a patient with stroke symptoms while Manning treats a boy who fell in the river and watches the family drama unfold.

Robin returns to the hospital with more complications; Rhodes faces competition from a new doctor.

An overflow of patients is rushed into Chicago Med following an apartment blaze and Rhodes tries to save a firefighter's life, while the two Halstead brothers face their own personal battle.

Caroline shares news that forces Dr. Charles to make a serious decision about their relationship. Maggie meets her sister's new boyfriend but danger may lie ahead. Dr. Rhodes experiences a huge loss. Dr. Choi and April face an unexpected challenge.

April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie's memory from the accident starts to return.

Marking the series milestone 100th episode, Dr. Manning and Dr. Charles assist in a complicated case helping a 4-year old who they quickly learn is no stranger to the ED. Dr. Marcel and Dr. Choi tend to a police officer with a mysterious gunshot wound to the abdomen. Relationships are put to the test as secrets are revealed.

Shocking information threatens Jack Dayton's surgery and the future of OR 2.0; Archer goes rogue to save a patient in need; Maggie questions her future at Med.