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Devon grows concerned when a mother's complaints go unaddressed after her delivery, and pushes Bell to take drastic measures. Conrad is faced with breaking the news to Nic regarding Jessie's worsening condition. Meanwhile, The Raptor, Mina and Kit spring into action when a mother and son enter the ER with devastating injuries.

When Billie's past mistakes are exposed, the team struggles to find a way to support her. The nursing shortage hits Chastain. A simple cleaning job goes horribly awry.

Conrad is pulled away from celebrating Gigi's birthday when Sammie comes into Chastain with 104 degree fever. Kit must call in a favor. A donor heart arrives for the governor.

Conrad turns to someone he thought he would never have to confront again to save Nic from being taking down by Lane.

An accident brings a familiar patient into the ER, the doctors must face the reality of how to proceed with the best care while questioning every decision. The Raptor and Leela treat a patient dealing the long-term effects of COVID

The surgeons work together to save the life of the Raptor's old mentor, Abe, who is their only inside source to Quovadis. Unfortunately, when Nic and Conrad take on a patient needing the hospital's only viable ECMO machine, they must decide between saving the life of Abe or saving the life of their younger, more stable patient. Meanwhile, Marshall puts himself in serious danger to help take down Gordon Page once and for all.

On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. When Devon discovers that his VIP patient has a life-threatening brain condition, the doctors ban together to perform a risky surgery. Meanwhile, Mina discovers that Adaku has a dangerous heart condition that puts her and the baby at risk, and Kyle forms a personal relationship with a patient.

When one of Chastain's own is brought into the emergency room with life-threatening injuries, the staff rallies around each other to try to save her life, while disagreements over how to best handle her care put Cain at odds with the rest of the doctors. Also, Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention. Meanwhile, Conrad turns heads when he shares data about Hemopleatin, and Kyle begins volunteering at the hospital.

Chastain is being dismantled, Doctors and surgeons are transferring and patients are panicking. Nic and Conrad announce they're going to be parents when another tragedy strikes.

Conrad, Kitt, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

Upon meeting with a high-profile soccer player suffering from mysterious symptoms, Conrad ends up back at Chastain and faces an angry Logan Kim. When Bell and the Raptor come up empty-handed in regard to a diagnosis, the doctors take note on how talented Conrad truly is. Nic springs into action when she notices Kyle falling into a deep depression and fears he could be suicidal.

When Cain becomes aware of an emergency situation breaking out at the hospital, he recruits Ezra to help keep it under wraps. Also, Nic works to come up with a support system for a patient in need of a lung transplant. Meanwhile, Kitt's son-in-law's condition continues to worsen.

When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

Bell's confidence in Quovadis continues to waver when the poster child for one of its medical devices, Henry Barnett, is rushed back into the ER, experiencing seizure-like symptoms. Meanwhile, Mina's past comes to light when her mother, famous Nigerian surgeon Dr. Okeke, pays a visit to Chastain, and Conrad makes a risky move when Henry returns to the hospital.

The surgeons are determined to shut down Quovadis after Henry Barnett almost loses his life due to a device malfunction. As Mina and Devon set out to find the truth, Bell, AJ and Conrad work to save the life of Chastain's favorite custodian, Simon. Meanwhile, one of Alec's old patients ends up in the ER, forcing him to question if he made the right choice to leave his old practice for Nic's clinic.

In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.

Conrad comes face to face with Nic's dad when he comes to Chastain with an extremely low heart rate. Billie advises her patient against surgery, but the patient's family ignores her recommendation.

Conrad's ex-fiancé, Catherine, is admitted to the hospital with abdominal pain that proves to be quite the medical mystery. As Conrad doggedly tries to figure out her diagnosis and fights the idea of Bell performing her operation, Nic gets some insight into Conrad's past. Meanwhile, Bell panics when Claire announces that she will be installing cameras in all operating rooms, Devon wracks his brain for the perfect birthday present for Priya and Lane realizes that Nic is suspicious about her clinic.

Conrad and Devon work tirelessly to save the life of Bradley, a fellow doctor who has fallen through the hospital skylight. As the team contemplates how and why he fell through in the first place, Dr. Bell looks back to when he benched Bradley for falling asleep during surgery. Amidst the madness, Mina is tasked with showing Chastain's new star cardiothoracic surgeon, Dr. AJ Austin (guest star Malcolm-Jamal Warner), around the hospital, but is caught off-guard by his volatile personality. Meanwhile, Nic finds renewed enthusiasm when she uncovers an oncologist who used to work with Lane, but while paying him a visit, she fears that she's being followed.

A blackout at Chastain creates tensions between the doctors.

Just when Mina and The Raptor can see their future together, an unexpected complication throws a wrench in their plans.

A case turns personal for Conrad when the donor-recipient of Nic's heart is admitted to the emergency room; Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision.