On the DVD short documentary, Claude Rains' daughter tells of a time when her father brought her to see a re-release of this movie in the theater in Pennsylvania, years after it was made. It was bitterly cold and his face was completely covered by a hat and scarf. When he spoke to ask for the tickets, the attendant immediately recognized his voice and wanted to let them in for free. Rains was quite upset at this and demanded that he pay full price.

The first time Claude Rains' daughter ever saw her father in a movie was in 1950, when he took her to a showing of 'The Invisible Man' in a small Pennsylvanian theater. While the film was playing, Rains was telling his daughter all about how it was made. The other theater patrons stopped watching the movie and instead listened to Rains' anecdotes.

In order to achieve the effect that Claude Rains wasn't there when his character took off the bandages, James Whale had Rains dressed completely in black velvet and filmed him in front of a black velvet background.

When screenwriter R.C. Sherriff came to Hollywood to write this film, he asked the staff at Universal for a copy of the H.G. Wells novel he was supposed to be adapting. They didn't have one; all they had were 14 "treatments" done by previous writers on the project, including one set in Czarist Russia and another set on Mars. Sherriff eventually found a copy of the novel in a secondhand bookstore, read it, thought it would make an excellent picture as it stood, and wrote a script that, unlike "Universal's" "Dracula (1931)" and "Frankenstein (1931)," was a closer adaptation of the book. This was fortunate, in that Wells had negotiated script approval when he sold the rights.

During the scenes with Una O'Connor, the hysterical pub landlady, James Whale struggled to control his own laughter, as he adored O' Connor's humor.

Boris Karloff and Colin Clive were both originally considered to play the lead. Karloff accepted until a dispute with James Whale broke up both their personal and professional relationship. Clive was tempted, but preferred to take a planned vacation back to England.

Gloria Stuart didn't enjoy working opposite Claude Rains. During filming when they had scenes together, she claimed her leading man kept backing her into the scenery and hampering her chances to perform. James Whale had to keep everything on an even keel by reminding Claude Rains that he had to share scenes with his leading lady.

Claude Rains' performance in this film inspired Mark Hamill's portrayal of the Joker.

According to the March 1975 issue of 'Films in Review', Robert Florey, Cyril Gardner, and Ewald André Dupont were all considered as director before James Whale was finally assigned.

The reporter who offers suggestions to the police chief was played by Dwight Frye. He is best known for playing Renfield in "Dracula (1931)." He also played Fritz in "Frankenstein (1931)" and Karl Glutz in "The Bride of Frankenstein (1935)."

Part of the original 'Shock Theater' package of 52 Universal titles released to television in 1957, followed a year later with 'Son of Shock', which added 20 more features.

As Jack rants to Flora about taking over the world, he strikes a pose typical of Italy's leader, the fascist dictator Benito Mussolini.

Chester Morris was initially considered to play Dr. Arthur Kemp.

By the calendar on the wall of the police station, around 1:01:28, it's the month of January. In the novel, the story begins in early February.

The Invisible Man is the only Universal "monster" that was never used later by Hammer company; unlike Dracula, Frankenstein's character and creature, Werewolf, Mummy.

The wall calendar in the police station, around 1:01:28, advertises "Old Chum / Canada's Favourite Tobacco".

The poster on the brick wall outside the police station, around 1:01:37, is advertising "The Royal Mail Line To South America" and features RMS Asturias.

In this movie the Invisible Man is a villain. The TV series The Invisible Man (2000) presented him in a sympathetic, humorous light.

Dr. Jack Griffin (Claude Rains) is one of the most bloodthirsty villains of the old "Universal" horror films, with a total of four murders depicted directly on-screen, the murders of eighteen search-party members off-screen, and the derailment of a train which results in one hundred deaths. In total, Dr. Griffin kills 122 people before he is killed.

According to information given on TCM before the movie is shown, Claude Rains was also chosen for the role because he spoke with such clarity and could be easily understood. This was important since his face was covered for almost the entire film.

Boris Karloff had been Universal's original choice for the role of the Invisible Man. Said to have turned it down because he would not be seen on screen until the end, in reality a quarrel with director James Whale broke up their relationship, and the director decided he wanted someone with more of an "intellectual" voice than Karloff. All of a sudden, his marked lisp had become an issue. Whale selected Claude Rains after accidentally hearing Rains' screen test being played in another room - until this film, Rains had primarily been a stage actor. Although he had appeared in one silent movie (Build Thy House (1920)), this was his first sound film.

Although he has the lead in the film and his character is onscreen for 95% of the film, Claude Rains never actually "appears" onscreen until the very last moment.

The basic framework of the story and the characters' names are largely the same as in H.G. Wells' novel, but there are several great differences, including: The novel takes place in the 1890s; the film takes place in 1933. In the novel, Griffin remains almost a completely mysterious person, with no fiancée or friends; in the film, he is engaged to a woman and has the support of her father and his associate. In the novel, Griffin is already insane before he makes himself invisible; in the film, it is the invisibility drug that causes his madness. In the novel, Kemp lives; in the film, Griffin kills him.

Of the top five classic Universal Pictures horror movies - "Dracula (1931)," "Frankenstein (1931),""The Mummy (1932)," The Invisible Man, and "The Wolf Man (1941)" - "The Invisible Man" is the only one that is sprinkled with humor. During filming of "The Invisible Man," Director James Whale could barely stay composed as one of his favorite female cast members, Una O'Connor, kept him, the cast, and the crew, laughing out loud during her scenes.