Most people watching "Night Flight" today most likely take air travel for granted and don't realize just how dangerous and insane the airmail service was in the early days of aviation. And, in the case of this film, this means travel across the Andes Mountains--something hard to imagine in a tiny biplane with an open cockpit. And yet, some crazy people did it! The film is a standout simply because of its amazing cast. It's hard to imagine John Barrymore, Lionel Barrymore, Clark Gable, Robert Montgomery, Helen Hayes and Myrna Loy all in the same movie, but here they are! Now this is impressive but is also a bit of a problem. Despite the film being in South America, almost no one in the film and none of the principle characters have a non-American accent! This isn't all that unusual for the time, but it is silly. What isn't silly is the plot. It's tense, non-sentimental and gripping throughout. And, it's well worth your time and an excellent tribute to these brave folks.
It's not too surprising that this story was taken from a novel by Antoine de Saint-Exupéry--the author of "The Little Prince". While "The Little Prince" seemingly has nothing to do with this film, it has a common thread--air travel, as there is a pilot who lands on the Prince's little planet. And, incidentally, the author was a pilot--and this would seem to explain his fascination with planes in these and other stories.
By the way, in the film you hear the term 'infantile paralysis'. This was another term for polio if you were wondering.