One of seven films Ricardo Cortez and Mary Astor appeared in together.
Dudley Digges, who plays the American Col. Jackson, was born in Dublin Ireland.
Mary Astor, Ricardo Cortez, and Florence Fair had all been silent film stars.
The idea of setting the film on the Orient Express may well have been inspired by Agatha Christie's "Murder on the Orient Express," which was published earlier that year.
An article in the 30 August 1934 edition of The Hollywood Reporter noted that Paul Muni was considered for the lead in this film.