The title is a common variation of a line from Hippocrates, the Greek Father of Medicine: "Life is short, art is long, decision difficult, and experiment perilous." The line is recited by Nick Bederaux in the film.
Both Cary Grant and Gregory Peck were lined up to star at different points in pre-production. Grant dropped out when producer David Hempstead left RKO. Peck had a prior commitment to David O. Selznick that prevented his participation in this film.
When Hunt is about to meet Nick (Paul Lukas) he encounters a row of aquariums. He comments to his companion, Clag, "Looks like something out of Jules Verne". In 1954, Paul Lukas would play Professor Aronnax in Disney's, "20,000 Leagues Under the Sea (1954)."
Hedy Lamarr was on loan-out to RKO for this film. She'd make only one more film for MGM before leaving the studio in 1945, ending her 7-year contract.
According to contemporary articles in The Hollywood Reporter, Maureen O'Hara and Laraine Day were considered for the female lead in this film.
"The Screen Guild Theater" broadcast a 30 minute radio adaptation of the movie on November 4, 1946 with George Brent reprising his film role.