In animation historian Jerry Beck's 1994 poll of animators, film historians and directors, this cartoon was rated the tenth greatest cartoon of all time.
The Jumbo-Gro juice was drank 10 times total, 1 time by the canary, (as a medication, by the hungry cat, almost acting like a doctor), 1 time by the dog, 4 times by the mouse and 4 times by the cat, until the bottle became empty, being drank so quick and often, (among the mouse and cat).
The mouse is reading a book entitled "The Lost Squeekend," a pun on the 1945 film "The Lost Weekend." The plot of that movie dealt with the dangers of alcoholism and bottles.
Some postwar humor here the adult cinema audiences would have appreciated. First, the empty freezer boasts furnishings and a sign advertising a room for rent, an obvious wink at the housing shortage facing returning veterans. And the equally empty sardine can has the plaintive notice, Kilroy was Here, a familiar phrase to GI's.
Coldernell, the name on the modern (for the time) icebox is a play on "colder than he*ll," which itself is likely a pun on popular product names like Frigidaire.