In this, the first Roadrunner cartoon, only the Super Outfit is ACME brand.

There was a gap of nearly three years between this and the second Road Runner cartoon, Beep, Beep (1952). Chuck Jones only intended it to be a one-shot cartoon, but the reception given by the public made him change his mind. He was especially persuaded by a letter from a captain in the Naval Air Force, who claimed that pilots were imitating the Road Runner's "beep beep" call while doing maneuvers.

First appearance of both Wile E. Coyote and Road Runner, collectively and individually.

In the early stages of his design, Wile E. Coyote's name was Don Coyote.

While the Coyote and Roadrunner are chasing each other through a freeway cloverleaf, the soundtrack plays "I'm Looking Over a Four-Leaf Clover".

The Road Runner's only vocabulary, "Beep, Beep!", was inspired by background artist Paul Julian who would make the sound while rushing down the hallways of the animator's offices. For this short, the sound effect was produced by Treg Brown who used an electronic horn called a Klaxon. When the gadget disappeared, Mel Blanc mimicked the sound for the second Road Runner short Beep, Beep (1952). That sound effect became the standard for all Road Runner cartoons thereafter.

The 'Road Runner' comics were very different from the cartoons: the Road Runner was named Papa Beep, he had three children called the little Beeps (and, in the picture book, a grandfather named Bigbeak Beep, all of whom were depicted as being identical to the cartoon Road Runner). In addition, the Coyote spoke and so did the Road Runner and his children (they spoke in rhyme except for the picture book, which was put out by Golden Books).

The title is a play on those of numerous films titled "Fast and Furious", dating back to a 1915 comedy short.