Jennifer Jones reportedly chewed garlic cloves before her love scenes with William Holden, which may have been an effort to deter her notoriously womanizing co-star. Considering how badly they were getting along, Holden suspected that it was Jones' attempt to annoy him.

Jennifer Jones, who was married to studio mogul David O. Selznick at the time of filming, complained constantly during the production, often yelling, "I'm going to tell David about this!" After complaining about William Holden, the two stars barely spoke to each other on the set. Finally, Holden tried to make peace, offering Jones a bouquet of white roses. She tossed them back in his face.

Jennifer Jones reportedly complained incessantly. Among other topics, she felt that her makeup made her look old. This might explain why the "yellowface" prosthetics (to make her eyes seem Asian) vary from shot to shot. Sometimes they're very obvious, and other times she seems not to be wearing them at all.

For his beach scene with Jennifer Jones, William Holden shaved the hair from his chest in order to get the "clean-cut" look supposedly favored by female moviegoers.

In one of the most classic examples of camera "point of view" editing, the hilltop love scenes were cut between Repulse Bay in Hong Kong from one direction, and a hill on the Fox Movie Ranch in upper Malibu, California from the other. The same ranch was used for both the film and television series MASH.

The aircraft that returns Mark to Hong Kong is Pan American World Airways N6535C, named "Clipper Mercury". It was a Douglas DC-6B, which entered service in 1952 and left service in 1961.

The only Best Picture Oscar nominee not nominated in either of the support acting categories that year.

The only Best Picture Oscar nominee that year to be also nominated for Best Song, and Best Cinematography (Color), and Best Costume Design (Color).

The decision to cast Jennifer Jones as Dr Han Suyin was widely condemned.

The film is based on a true story, recorded in Dr. Han Suyin's autobiographical novel, "A Many-Splendoured Thing". The journalist, Mark Elliott, William Holden's character, is based on Ian Morrison, a British correspondent who had an affair with Dr. Han in Hong Kong. As depicted in the film, Morrison was killed in Korea in 1950, while covering the war there.