Dale Robertson, a natural right-hander, taught himself to draw his gun and shoot left-handed, so that his character Jim Hardie would be more distinctive.

The horse Dale Robertson rode throughout the series, named "Jubilee", was his own.

The steam engine shown in the series was the number 3 from Sierra Railroad in Jamestown, California, many scenes were also shot in what is now Columbia State Park, both near Sonora, California.

Wells Fargo did have regular and Special Agents, who carried badges, and had some law enforcement powers. Jim Hardie (Dale Robertson), who was a Special Agent, only showed his badge on a few episodes.

The locomotive used on this show was the same one used on "Casey Jones (1957)."

The pilot episode, titled "A Tale of Wells Fargo," was aired on the "Schlitz Playhouse" anthology TV series. The "Tales of Wells Fargo" series was launched the following year.

As one of the co-creators, this was the first series created by Gene Reynolds.

In addition to the weekly shoot-em-up on television, there was a "Tales of Wells Fargo" comic book published by Dell with a full color cover featuring Dale Robertson. This was back in the days when a comic book cost a dime.

The closing credits in Season 4 and 5 showing a locomotive moving along the plains was re-used as the same stock footage for the ending credits of "The Man Who Shot Liberty Valance."

In Episode 32 The Tall Texan, the first shot of the train immediately after the open has a very visible power line with a transformer on a utility pole in the background.