Joan Crawford was set to play Roberta Carter, but shortly before production was to begin, she dropped out because she didn't want to work over the Christmas holidays. However, according to Christina Crawford, another reason Joan dropped out was because she didn't want to work on the same lot as her daughter, who would be filming at the same time.

Bette Davis and Joan Crawford were both considered for the role that eventually went to 'Mary Astor (I)'.

The voice of the character "Mark Steele", played by the uncredited Bill Bradley, is actually that of the film's director José Ferrer.

Brett Halsey and Luciana Paluzzi, who played husband and wife in this film, were actually married at the time.

Rosemary Clooney, who sings the movie theme song "The Wonderful Season of Love", was married to the film's director, José Ferrer, at the time the movie was made.

Uncredited feature film debut of Bob Crane, who portrayed Peter White.

The Peyton Place franchise was a major influence on Twin Peaks decades later. Both series have been a film and a prime-tie soap opera. The original Peyton Place featured Russ Tamblyn who also appeared in Twin Peaks. Director Jose Ferrer worked with creator David Lynch in Dune, and was the father of Twin Peaks cast member Miguel Ferrer.

The filming locations and interior sets of the MacKenzie house and The Tweed Shop (the store that Constance owns) are completely different from the original film. The exterior scenes for "Return To Peyton Place" were shot in Mamouth, California (for the skiing sequences) and at Fox's Malibu Ranch. The interior sets are "significantly smaller" than in the first film, as noted by film historian Sylvia Stoddard.

Key characters in the original - Doctor Matthew Swain, Betty Anderson, Leslie Harrington and Norman Page - all appear in the sequel novel but were completely left out of the film.

Producer Jerry Wald was notorious for announcing any possible casting choice that crossed his mind, in order to keep his projects in the headlines during pre-production. In this instance, he announced Jessica Tandy, Margaret Leighton and Ginger Rogers as possibilities to play the role ultimately played by Mary Astor.

In 1960, Hedda Hopper reported that producer Jerry Wald was trying to lure Norma Shearer out of retirement, in order to play the mother of a teenage girl. This was the role created by Lana Turner in the original, which eventually went to Eleanor Parker in this sequel. The announcement was probably just a publicity stunt as, at the time, Shearer had been off-screen for 18 years and was 58 years old.

According to film historian Sylvia Stoddard, at the time the film went into production, Tuesday Weld was a light blonde, but because Carol Lynley and Eleanor Parker were playing mother and daughter, Weld's hair had to be darkened so that she would be distinguishable from the other two actresses. This, despite the fact that she was taking on the role originated by the very blonde Hope Lange.

Lewis Jackman (Jeff Chandler) drives a 1961 Chrysler Imperial Convertible; Mrs. Carter (Mary Astor) drives a 1956 LIncoln Premiere 4-door sedan; Selena (Tuesday Weld) drives a 1941 Mercury convertible;

Gene Tierney was originally announced for the Eleanor Parker role.

In this sequel, Allison writes a book based on her experiences in the town which were depicted in Peyton Place (1957). She has given the real people fictitious names in her book and Selena's stepfather is called Lucas in it. When Selena tells her boyfriend what happened between her and her stepfather, she says "His name wasn't Lucas. It was Luke!" However, he is indeed named Lucas in both the previous film and the Grace Metalious novel it is based on.

As in many cases of book-to-screen adaptations, quite a few things were altered between the book "Return to Peyton Place" and the movie. Some of these include: Allison MacKenzie had several men vying for her attention in the book, but in the film she is partnered solely with Lewis Jackman. In the book, he dies in a horrific car crash soon after making love to Allison (she is in the car, too, but survives). The book includes the continuing story of Betty Anderson and her small son and their relations with Lesley Harrington (her son's grandfather). This entire story is left out of the film. Selena Cross has two love interests in the book. Neither one shows up in the film, though Nils, the ski instructor, has a few of the traits of one of them. In the novel, Constance and Michael Rossi share an earthy, sometimes randy relationship. They are much more conservative in the film with the character of Mike Rossi heavily altered from a sexually-charged Italian to a somewhat milquetoast gentleman. One huge change is the character of Ted Carter's wife. In the book, she's a blue-blooded society girl named Jennifer and is presented as a sadomasochistic nymphomaniac with lots of cunning and deviousness. Needless to say, Roberta Carter (Ted's mother) can hardly stand this and plots to murder her, only she winds up being killed herself. In the film, Ted marries a young girl behind his mother's back and she hates her for that and for her other flaw - she's Italian! She is named Rafaella (no doubt to accommodate the actress playing Raffaella, an Italian with a noticeable accent). In the finished film, there is never any indication that foul play will occur between the ladies, despite their hatred for one another. However, early print ads for the film refer to Roberta Carter's plans to murder her daughter-in-law and the trailer features the Carter house engulfed in flames. So somewhere along the line (after filming was completed) it was decided to abandon the whole murder plot entirely and just end with the Town Hall meeting. Also present in the book, but absent from the film, are the characters of Selena's brother Joey, Allison's friend Stephanie and a famed actress called Rita Moore.

A sequence featuring the climactic fire that burned down Roberta Carter's (Mary Astor's) house was cut from the final film. A snippet from the scene can be seen in the trailer on the DVD.