Raymond Burr injured his eyes working on the series. Being in a wheelchair, he had to look up directly into the hot lights used to film his scenes, and his eyes were slightly burned.

Besides the injuries to his eyes, Raymond Burr suffered great physical stress from being in the wheelchair for extended periods of time.

Barbara Anderson left the show after the 1970-1971 season because of a contract dispute.

In the pilot, Ironside wears a bandage on his right hand. This was not make-up. Raymond Burr injured the first two fingers of his hand when he fell after being "shot".

As the show progressed, Mark went from being Ironside's bodyguard, to a full fledged police officer and eventually became an attorney in the final season. In The Return of Ironside (1993) he had become a judge.

Steven Bochco, who would later became one of the most successful television producers of the 1980s and 1990s, worked on the series very early in his career. He had been hired by Executive Producer Frank Price at the start of the first season to write a few extra minutes worth of scenes in the first six episodes, which were too short. After looking at these episodes, Bochco asked Price if it was really necessary for him to do this for all six because he didn't think the show would last that long. According to Bochco, Price was not happy with the remark, and this was the start of a strained relationship between the two of them that continued when Price was in charge of Universal Television and Bochco was a writer there.

NBC abruptly cancelled the series in 1975 without airing three episodes: "The Organizer", "The Rolling Y", and "A Matter of Life or Death". They eventually aired in syndication.

In many of the early episodes, Ironside and his team would drive around in an armored car. However, during the second season they replaced it with his more familiar van.

This series' distinctive theme music was among the first such high profile assignments for now legendary composer Quincy Jones.

A couple of episodes on the show acted as the pilots for the short-lived series Sarge (1971) and Amy Prentiss (1974).

Dana Wynter guest-starred playing different characters in two episodes. She portrayed Ironside's wife in The Return of Ironside (1993).

Ed served in the Marines before he became a police officer.

Three of Raymond Burr's former Perry Mason (1957) cast mates made appearances on the show; Barbara Hale, Wesley Lau, and Richard Anderson.

The "pilot" for this series was not a one hour episode, but a two hour TV movie which was a ratings success when it aired on NBC in 1967 - a common network practice at the time.

In the show, Raymond Burr played a wheelchair-bound hero, which is ironic, since his role in Rear Window (1954), he played a villain fighting a wheelchair-bound hero.

The interior set of Ironside's office was originally constructed for Alfred Hitchcock's 1964 drama Marnie, where it appeared as one of the places of employment whose safe was robbed by kleptomaniac Tippi Hedren.

In some episodes of season 1 he has a powered wheelchair in other episodes it is a manual chair.

In 2013, a remake of the series aired on NBC. It attracted controversy for casting non-disabled actor Blair Underwood as a disabled character, and was universally reviled by critics for having a far more gritty and violent tone. After nine episodes-only four of which were broadcast-critical derision and declining ratings, it was axed.