The series dropped out of the top 10 Nielsen ratings in its fifth season. This was the first time that a series starring Lucille Ball was not in the top 10. Because of this, Ball wanted to end the series, and a final episode was filmed. But CBS convinced Ball to return for one more season.

The number one television show on CBS during the 1970 to 1971 season.

Lucille Ball broke her leg shortly before the fifth season began. People worried the show would have to end, but the show continued with Lucy in a leg cast for part of the season.

The show came about because of a business transaction. In 1968, The Lucy Show (1962) had been running for six seasons, and the ratings remained solid. Lucille Ball sold the Desilu studio that year. So, in order to retain ownership of her series, she ceased production on The Lucy Show (1962), and created this show. The new series had a slightly different plot, and new character names (plus roles for Lucy's kids), but continued with the same cast and timeslot.

The season four finale, "Kim Finally Cuts You-Know-Who's Apron Strings", was a pilot for a spin-off, starring Lucie Désirée Arnaz, which never sold.

Originally, Doris Singleton, who played the recurring character of Caroline (originally Lillian) Appleby on I Love Lucy (1951) was supposed to co-star on this show. Her character was supposed to be Harry's efficient morning secretary, opposed to Lucy, his scatterbrained afternoon secretary. Her character was dropped after the first episode, because it was decided to show more of Lucy's family life with the kids, than her job.

Desiderio Alberto Arnaz IV appeared on The Brady Bunch (1969) as the object of Marcia's crush in season one, episode twenty-two, "The Possible Dream" when he was appearing on this show.

One of the strangest episodes was when Lucy Carter meets her real-life alter ego, Lucille Ball. This being the 1970s, they did a split screen, one side had Lucille Ball with her trademark red hair (Lucy Carter), the other side had Lucy glammed up, and wearing a black wig (Lucille Ball).

The first season episodes were co-produced by Paramount Television.

Desiderio Alberto Arnaz IV decided to leave the show after the third season to pursue a movie career. However, after his departure, he made one more appearance in season five, episode five, "Lucy and Joe Namath".

Jayne Meadows, an old friend of Lucy's, agreed to do a cameo on "How to Stop a Marriage". She said in a recent EMMY TV LEGENDS interview that the script was one of the worst she had ever seen; it made no sense. Lucy apologized; saying they had spent all their time on LUCY MEETS LIZ AND RICHARD (Elizabeth Taylor and Richard Burton) on the previous episode; and this episode was the next one; was so bad because they bought it off the market. Meadows said "they probably spent about 50 cents on it it was so bad. It made no sense at all."

According to the Lucille Ball Biography "Ball of FIre", in 1973, when this show dropped out of the ratings top thirty, and in fact, Lucy dropped out of the top 10 since she started doing I Love Lucy (1951); a CBS executive visited her at her home and started making suggestions for making Lucy's show hipper, more like other hits on the air at the time like Maude (1972), or The Mary Tyler Moore Show (1970). Lucy then called Bill Paley, the CEO and Chairman of the Board at CBS at the time, and said "Bill, will you get this guy out of here?" Paley complied and the CBS executive left. But Lucy should have listened, the show was cancelled in 1974 shortly after that meeting.

Rowan & Martin's Laugh-In (1967), which was in competition with The Lucy Show (1962) and this show, made fun of their competition frequently by having the cast say goodnight and goodbye to Lucy at the end of the show. "Goodbye Lucy" they would say and salute. Lucy responded on a talk show: "Do they think that's funny?" Lucille Ball literally got the last laugh, though. Rowan & Martin's Laugh-In (1967) was cancelled in 1973, one year before this show was cancelled.

Lucy invited her friend Ginger Rogers to be on the show as another star Lucy was stalking. Ginger and Lucy met at Ginger's mothers school; Lela Rogers ran a famous school for young actresses; to train them to get into Broadway and Hollywood; which Lucy attended; along with Ginger; when they were about 20.