Briefly ended Star Wars: Episode IV - A New Hope (1977)'s fifteen-week reign at the number one spot at the box-office in October of 1977, before Star Wars returned to the top spot the following week.

According to Screenwriter Larry Gelbart, Director Carl Reiner initially envisioned his oft-partner Mel Brooks playing God, and Woody Allen playing Jerry Landers.

Donald Pleasence only had two lines.

When Jerry is in the hotel room about to give God a quiz, The Dick Van Dyke Show (1961), is playing on the television. Director Carl Reiner created and acted in The Dick Van Dyke Show (1961).

The first of two times that Teri Garr plays a woman who is married to a man who is sane, but considered crazy because of something he saw. The other being Close Encounters of the Third Kind (1977).

The first of three "Oh, God!" movies starring George Burns.

Though George Burns was given top billing in the opening titles and all publicity, John Denver was given top billing on the end credit roll.

DIRECTOR CAMEO (Carl Reiner): As Dinah's Guest.

Remade in India as " Yuhi Kabhi".

Throughout all three movies in the franchise, all of the main characters have something in common. They all have a background in music. John Denver was a famous folk and country singer. Louanne got her start with the starring role in a musical theater production of Annie. Ted Wass also began his career with stage musicals. Even George Burns himself got his start as a street performer and eventually vaudeville.

Included among the American Film Institute's 2000 list of the 500 movies nominated for the Top 100 Funniest American Movies.

In a way; the EXORCIST movie can be seen as the flip side of OH GOOD BOOK TWO. The Exorcist is a movie about a little girl overtaken by the Devil; or a demon; with the purpose to spread the word that Satan is gaining power; will be destroying the world soon; and to make people despair; etc. In Oh Good Book Two the little girl is overtaken by the presence of God to spread his message of hope, to inspire people. In Oh God Book Two George Burns even says to the girl, Tracie, (Played by LuANNE), "I don't like to mess with kids. There are so many movies about kids going through so much trouble, having so much stuff happen to them... Terrible things. I figure kids have enough to worry about; I don't need to mess with them to spread my word." This is a direct reference to how the demon terrorizes Linda Blair in The Exorcist; and how the Oh God movies are a response to that; in a sense.