Originally, Producer Derek Granger asked Anthony Andrews to play the role of Charles Ryder. Andrews, however, felt he was better suited for the part of Sebastian Flyte. Jeremy Irons, Granger's first choice for Sebastian, preferred to play Ryder, so the two actors swapped roles.

Castle Howard, which was used as the location for much of the series, was owned by George Howard, who, at the time, was the Chairman of the BBC, a rival of the network airing the series. He nonetheless agreed not only to allow his castle to be used, but served as a Technical Advisor, and supplied many of the props for the production, while also advising the filmmakers in ways to avoid incorrect portrayals of life in such an environment.

Sebastian's teddy bear, Aloysius, was based on a real one called "Archie", which belonged to Writer John Betjeman, one of author Evelyn Waugh's friends from his days at Oxford University.

The ship in the storm scenes was unused footage from The Poseidon Adventure (1972).

Sir Laurence Olivier was offered his choice of roles in either Lord Marchmain or Edward Ryder (which ultimately went to Sir John Gielgud). Olivier picked Lord Marchmain, but later regretted the choice as he realized that Edward Ryder was actually a much stronger role.

The character Cousin Jasper is based on author Evelyn Waugh's own brother Alec, who delivered a similar "exasperated warning" to his brother while at Oxford.

Production was delayed for several months by a strike of ITV technicians in 1979. When filming resumed, Director Michael Lindsay-Hogg was no longer available because of commitments in the U.S., so he was replaced by Charles Sturridge for the scenes filmed in Oxford and many of the ones filmed at Castle Howard ("Brideshead").

When filming the scenes during the storm on-board the ocean liner, the small cabin sets were made to rock from side to side, but this could not be done for the much larger dining room set, so Producer Derek Granger stood on a chair behind the camera and waved a stick from side to side to indicate to the cast which way to lurch and sway.

In episode four, "Sebastian Against the World", Lady Marchmain reads aloud the G.K. Chesterton "Father Brown" story "The Queer Feet", in which Father Brown says of a criminal "I caught him, with an unseen hook and an invisible line which is long enough to let him wander to the ends of the world, and still to bring him back with a twitch upon the thread." The episode titles (and the chapter titles of the book) "The Unseen Hook" and "A Twitch Upon a Thread" are a reference to this, as a metaphor for the way in which the characters are able to wander the world according to their free will until they are ready and receptive to God's grace, at which point He acts in their lives and brings about a conversion.

In 2007, this mini-series was voted the seventh favorite series to air on PBS' "Masterpiece Theatre" in the U.S. Unfortunately, it had never aired there. It was shown as part of "Great Performances".

During the enforced break in filming caused by the ITV technicians' strike in 1979, it was noticed by the cast and producer that an important scene (Julia in tears while sitting by the fountain at night) had not been included in the script. They decided that it should be put in. In fact, during filming, the cast and crew had only a vague idea how many episodes would result. The final script was apparently not written by John Mortimer. Producer Derek Granger simply selected scenes and lines from the pages of the novel, though Mortimer still had to be credited for contractual reasons.

Director Charles Sturridge married Phoebe Nicholls (Cordelia).

At the time of series release, it was the most expensive British television project ever made.

In December 1981, Geoffrey Burgon's theme music was released as a single and reached number forty-eight on the U.K. Singles Chart. It is the only piece by Burgon to have entered the mainstream pop chart.