The film was the second of three collaborations of Gilda Radner and Gene Wilder. Their other films were Hanky Panky (1982) and Haunted Honeymoon (1986). While in France to promote this film, the pair took a brief break from their professional duties and quietly married.

The film has been memorable due to its theme tune "I Just Called to Say I Love You" sung by Stevie Wonder which won the Academy Award for Best Song. The soundtrack was also composed by Wonder and also featured performances by Dionne Warwick.

Due to its success at the box-office, the picture has been attributed as the initiator of a Hollywood cycle, even Hollywood practice, of remaking various French films, particularly comedies, for an American version.

The man posing as a pilot in the photograph of Charlotte's husband is Jean-Loup Dabadie, one of the original screenwriters of the French film Pardon Mon Affaire (1976) that inspired this movie.

Debut and breakthrough film role of Kelly LeBrock.

Gene Wilder's most successful film as a director at the box-office. Wilder performed three roles on this movie, being also the writer and lead actor. Despite its success at the box-office, the movie was Wilder's penultimate film as a director, Haunted Honeymoon (1986) being his last.

Melanie Griffith turned down the role of Charlotte in order to play Holly in Body Double (1984).

The movie blatantly used the famous Marilyn Monroe dress flying above the street grate from The Seven Year Itch (1955), but exchanging the color from white to red. The image was the dominant one used in the film's press and marketing materials, particularly movie posters. This movie was not the first to do this in recent times, as the Barbra Streisand comedy All Night Long (1981) had used it, where Streisand is seen climbing up a pole wearing a violet dress with three male characters beneath her.

The film was adapted from the French film Pardon Mon Affaire (1976). Gene Wilder adapted an Italian film, "The White Sheik" (The White Sheik (1952)), as The World's Greatest Lover (1977).

Several of the cast members in this film were related to Gene Wilder in real-life, or otherwise connected to him. Gilda Radner was his wife (fiancée at the time this movie was filmed), Charles Grodin, his best friend, and Buddy Silberman, his cousin (Gene's name was originally Jerry Silberman).

While not the first movie to be given a PG-13 rating, it is the first PG-13 movie to feature frontal (but brief) nudity by Kelly Le Brock.

One of two "boudoir farce" movies, in which Joseph Bologna appeared, in 1984. The other being Blame It on Rio (1984).

Though the film was successful at the box-office, Hollywood never produced a sequel to this movie, unlike its source French film Pardon Mon Affaire (1976), which generated a follow-up a year after it was made, called Pardon Mon Affaire, Too! (1977).

Some movie posters for this film featured a preamble that read: "Shy, quiet Teddy Pierce wanted a little adventure. And one day it walked into his life in a red silk dress. Now his wife is packing a gun. His friends are going nuts trying to cover for him and he's about to get caught with his pants down on the six o'clock news. Be very careful of what you want... Because you just might get it."

Film debut of Thom Mathews.

The film is not a remake of the earlier same titled movie The Woman in Red (1935).

The English titles of this film's source French film, of which it was a remake, were "Pardon My Affair" (Pardon mon affaire) and "An Elephant Can Be Extremely Deceptive" (Un éléphant ça trompe énormément).

This film was released eight years after the Yves Robert' French film Pardon Mon Affaire (1976), of which it was a remake.

Ed Begley, Jr. was the voice of the television reporter voice-over at the end.

The slogan for the public transportation campaign, for which Kelly LeBrock advertised, was "She's Running Again!"

Two actors in this film play characters with the same names as their own. Michael Huddleston played Mikey, while Joseph Bologna played Teddy's friend Joe.

This is the only film where Gene Wilder and Charles Grodin appeared together.