The ghost-like image of Rod Serling flashes across the screen during the opening credits. He is the only host, if a previous one, of The Twilight Zone to be seen, since this is the only series where no narrator showed himself on-screen at any point.

Charles Aidman, the host of CBS episodes of the show, appeared in two episodes of the 1950s version: The Twilight Zone: And When the Sky Was Opened (1959) and The Twilight Zone: Little Girl Lost (1962).

Assuming the new Twilight Zone would be a huge hit with adults who had grown up on the original, CBS pre-sold the syndicated rerun rights with a "guaranteed" number of episodes. However, the show was ultimately a failure and was cancelled after two seasons. CBS quickly made deals to produce additional episodes for syndication in order to fulfill the guarantee. In syndicated versions of this show, Robin Ward narrates all of the episodes, including the episodes which originally featured narration by Charles Aidman. MGM/UA felt that this would give the series a greater sense of uniformity. Also, this way they didn't have to pay residuals to Aidman, but only to (the considerably cheaper) Ward.

Showrunner Philip DeGuere, Jr. shared the same agent as fantasy writer, George R.R. Martin. The agent provided a copy of Martin's fourth novel, "The Armageddon Rag", a rock and roll dark fantasy, to DeGuere because he was a Grateful Dead fan. DeGuere liked the novel so much that he planned to write and direct an adaptation, but the novel failed in sales. DeGuere and Martin stayed friends, and DeGuere recruited Martin for his first Hollywood position as a staff writer in this Twilight Zone outing.

The Hollywood tower of terror in Disney's Hollywood Studios theme park is based on this show.