According to interviews with show creator Christy Marx, while all of the Holograms' first names were already chosen by Hasbro (the creator of the toy line), she gave them all last names that corresponded to scientists who were at the time working on holographic technology. Similarly, she named villain Eric Raymond after her own brother.

The show's title and main character were originally going to be named "M," but "Jem" was chosen to avoid copyright problems with MTV.

The character of reporter Hector Ramirez would appear in various TV shows made by Sunbow. Besides appearing in Jem, he appeared in episodes of G.I. Joe (1985), InHumanoids (1986), and The Transformers (1984).

The Rockin' Roadster toy contained a real working FM radio.

In one scene where people are watching several television screens, you can see a news report of an attack by the Inhumanoids (who were monsters from a show of the same name, InHumanoids (1986), also produced by Sunbow).

After M was ditched as the name of Jem, several other names were tested before the final names were decided upon. Jem was Misty, Jerrica was Morgan, Kimber was Aja, Aja was Jade, Stormer was Roxy and Roxy was Ru.

A Jem movie was in the works but never got made due to the Transformers and My Little Pony films underperforming at the box-office. However, a new movie titled "Jem and the Holograms" has been produced by Universal and was released in October.

Due to low sales of the toy line in 1987, Hasbro decided not to issue a third edition of it in 1988, although they did make doll prototypes of three new Jem dolls, and of characters introduced in the third season: The Stingers, Astral and Regine, and also a new character not introduced in the cartoon, Graphix. With Hasbro canceling the toy line, the series was also cancelled. Series creator Christy Marx was given the chance to write the final episode, which she wrote as a closing chapter in the series with the Holograms, the Misfits and the Stingers calling a truce.

The actors who did the voice acting worked in a studio located in Los Angeles, while the singing voices were recorded by professional singers in New York City.

Despite the show being American, most of the animation was provided by Japanese studio Toei Animation.

The show started out as 6-minute segments shown on Super Sunday (1985), which aired in late 1985. All these segments, which form the first five episodes, were later slightly revised when they were released as a VHS tape in 1986. The show went in full production and then started airing on its own in July 1986 until 1988.

Each episode would usually feature three songs with music videos lasting around one minute. Usually it would be two new Jem songs and one new Misfits song. In the second and third seasons, some of the songs were re-used for these episodes, especially the ones by The Misfits. The Jem and The Holograms song "Like A Dream" was the only song in the series to appear in three different episodes.

Unusually for a rock band, Jetta's main instrument is the saxophone, although only three Misfits songs ("I Like Your Style", "Trapped" and "Free And Easy") feature sax lines. She is seen playing the sax on other videos despite the songs featuring no sax parts, except on the "Congratulations" video where she's playing a keytar. In the original script of her first episode appearance she was a bass player, hence the initial rift with Roxy, but it was changed to a saxophone when the episode was animated.

Head writer Christy Marx named Jerrica and Kimber's late father, Emmett Benton, after Dr. Stephen Benton, a pioneer in holographic technology.

Each Jem doll was packaged with a cassette single featuring the show's theme song "Truly Outrageous" and two other songs unique to each character. More than three million dolls were sold between 1986 and 1987, earning the theme song triple-platinum sales status.

Episode #26, "Glitter and Gold", served as a standalone bridge episode between the first and second seasons made at the request of Hasbro. The episode served to introduce the second edition of the toy line, which had been just released when the episode aired, most noticeably the "Glitter and Gold" Rio and Jem dolls and the "Rock n' Curl" Jem doll and the Glitter and Gold Rockin' Roadster toy car. Many of the characters in this episode wear dresses which were sold as separate alternate fashions for the dolls. Also, the character of Clash, who had had pink hair with a streak of aquamarine up to that point, appears for the first time with purple hair to match the doll. Although Clash would continue to have purple hair for the rest of the series, this is the only episode where she has long, wavy hair like the doll.

Jem's original name was going to be "M" - which was meant to imply Music, Magic, and Mystique.