The model of the Enterprise used in the opening credits is so detailed, a tiny figure can be seen walking past a window just before the vessel jumps to warp speed.

As with the original "Star Trek" (1966) series, each episode begins with the captain reciting the famous opening monologue, "Space, the final frontier...." In recognition of changes in language conventions and style, the conclusion of the monologue has been altered. Whereas the original series ended with "where no MAN has gone before," TNG uses "where no ONE has gone before."

"Descent, Part 1" is the only episode of the series to show the episode credits during the teaser.

The pilot episode "Encounter at Farpoint" has the end credits in a "scroll up" format. All subsequent episodes display the end credits in a "slideshow" format.

The 1991 episode "Unification, Part 1" is dedicated to the memory of Gene Roddenberry.