Midnight Run has thrills, excellent performances, touching moments, slick plotting, lively dialogue, plenty of laughs, beautiful locations and finely detailed direction. It's an across-the-board success, the best new movie I've seen in years. [20 July 1988]
A performance like De Niro's, in a well-made entertainment like Midnight Run, is cheap at any price. And capable of restoring the audience's faith in the form. [25 July 1988]
Roger EbertChicago Sun-Times
Whoever cast De Niro and Grodin must have had a sixth sense for the chemistry they would have; they work together so smoothly, and with such an evident sense of fun, that even their silences are intriguing.
Dave KehrChicago Tribune
Graciously filmed by Martin Brest and imaginatively performed by Robert De Niro and Charles Grodin, the tired concept yields a steady stream of little discoveries and surprising insights that add up to some uncommonly rich comedy. [20 July 1988]
Michael WilmingtonLos Angeles Times
There isn't a single performance in Midnight Run that doesn't have a pulse, that doesn't show the actors at their best or near-best, especially De Niro. [20 July 1988]
Brad LaidmanFilm Threat
The funniest buddy movie ever and a generally daffy one at that. It features some of the most genuinely stupid and amusing tough guys in the history of cinema, and a tantalizing slow burn by Deniro.
Midnight Run is two films. One is a succession of bright, razor-edge, nutty dialogues between two men. The other is the plot that keeps them together, which is stale and full of boring violent-comic action. [29 Aug 1988]