A line from this film where Turner yells at Hooch to not eat the car was used in animation test footage for Toy Story (1995). When Tom Hanks saw the test footage, it convinced him to take on the role of Sheriff Woody.
Henry Winkler was originally hired as the director. But, two weeks into filming, he was fired by Disney executive Jeffrey Katzenberg who was dissatisfied with Winkler's work.
Scenes with Turner walking Hooch took a lot of takes as 'Beasley The Dog' was so strong, Tom Hanks frequently dropped the leash.
Jack Nicholson, Bill Murray, and Chevy Chase were all considered for the role of Turner.
A pilot for a "Turner & Hooch" television series was filmed, starring Thomas F. Wilson (of Back to the Future (1985) fame) and Wendee Pratt. It aired on the The Magical World of Disney (1988), but the series was not picked up.
The two other investigators are Foster and McCabe which were the same names of the second team to tail Axel Foley in Beverly Hills Cop (1984), also written by Daniel Petrie, Jr.