When Babe is in his hotel room his door opens and reveals the room number across the hall to be room #714 - an obvious reference to the total number of home runs the Babe hit during his career.

When interviewed during production of the film, John Goodman noted the irony of having to lose weight to play the part of Ruth.

The minor league Danville Dans stadium in Danville, Illinois, was the one used for Fenway Park and Forbes Field, as well as being seen in black/white news footage.

Every ballpark except Fenway Park was portrayed by Wrigley Field (Cubs fans can tell just by looking at how the grass is cut by 1st and 3rd base).

In the film, "Jumping" Joe Dugan is portrayed as Ruth's teammate and mentor since Ruth's rookie year in Boston in 1914. In real life, Babe Ruth was sold to the Yankees in 1920. Joe Dugan didn't join the Red Sox until 1922 and the two weren't teammates until Dugan was traded to the Yankees midway through the 1922 season.

The transportation scenes were filmed at the Illinois Railway Museum in Union, Illionis. The museum's Frisco 1630 steam locomotive and the observation car "Inglehome" were used. The museum's 1859 Chicago horse car was moved to Chicago's Webster Street for a cameo role as a Baltimore horse-drawn tram in the segment about Ruth's childhood days.

When he's in his last days of playing and he hits home runs, he can not touch first and walk back to the dugout , he's required to touch all the bases in order, not just first. Now if Ruth got a single, he could have a pinch runner but he would be out of the game.

Wayne Messmer plays the Yankees announcer. In real life, he is affiliated with the Chicago Cubs, having sung the National Anthem hundreds of times at Wrigley Field and also served as the public address announcer.

In addition to the myth of the "called shot", the movie also perpetuates the myth that Babe Ruth promised a dying kid in a hospital that he would hit a home run for him. This myth was based on the fact that Ruth often did visit children's wards in hospitals and did on occasion promise to hit home runs for sick children. But it is not known if he had ever fulfilled such a specific request for a dying kid.

Like the film "The Babe Ruth Story", this film perpetuates the myth that Babe Ruth dramatically pointed to center filed and "called his shot" in the 1932 World Series against the Chicago Cubs. In reality, Ruth did not actually point to the stands. According to both Yankees and Cubs players who were still living and interviewed over the years, they said that while Ruth was at bat, the Cubs players were razzing him on each strike, to which Ruth sarcastically held up a finger for each strike (as shown in the movie) as if to say "It's only strike one", "It's only strike two". Then, according to Cubs catcher, Gabby Harnett, Ruth said "It only takes one to hit it." Ruth called his shot in the sense that he predicted that he was going to hit a home run. But he never actually pointed as shown in the movie.

When the babe (john goodman) gives away a suit to jumping joe he opens the hotel rooms door. The room number visible across the hall is 714. Same as the number of homeruns in babe ruths career

James Cromwell went on to star in another movie with a similar name just 3 years later about a pig - Babe (1995).

Both Beep Iams and Brendan Hutt are misbilled as Boys from St. Mary's. They were in fact, Boys in the Stands at Fenway Park, although their scene was cut in pre-production.

Final film appearance of Jeffrey Wiseman, who played Mitch Murphy in Home Alone (1990).