Bruce Campbell cited Brisco County Jr. as his favorite role. On the special DVD featurette he commented "it was the most exhausting, physically demanding year of my life. It was also the best." The other cast members all shared similar sentiments.

Though the show only lasted one season, the series' majestic theme song composed by Randy Edelman found a new life as part of NBC's sports productions, namely during NBC broadcasts of the World Series and the Olympic Games (played while announcing the upcoming events).

Bruce Campbell did a standing back flip during his audition. His reasoning was that because the show would be very action-packed, he wanted to impress the producers with his ability and willingness to handle himself physically.

To signal important or dramatic turns in the plot, and often when Brisco County Jr. is introduced an eagle can be heard screeching in the distance.

The pilot episode The Adventures of Brisco County, Jr.: Pilot (1993) featured a reporter named Jonah Collier who was played by Dan Gerrity. Collier was originally supposed to be a recurring character who would provide plot explanation at the beginning of episodes while covering news stories. The character was removed because the producers decided that the presence of Socrates Poole and his role as a provider of plot exposition made Jonah Collier unnecessary.

In the Special Features DVD, writer Carlton Cuse said that when coming up with ideas for the series, he was studying various B-movies from the 50s and 60s, and noticed that many of them were Westerns or Sci-Fis. Cuse then decided to create the series as a combination of the two, creating it as a Western, but with sci-fi elements.

Dixie Cousins was originally supposed to be a one-time character, with Professor Wickwire's daughter Amanda (from The Adventures of Brisco County, Jr.: Pilot (1993)) serving as Brisco's recurring love interest. However, due to the popularity of Dixie - as well as the great chemistry between Bruce Campbell and Kelly Rutherford - Dixie became a regularly recurring character, while Amanda is never seen again despite her father's importance in Brisco's missions.

Brisco's horse was billed in the credits as "Comet the Wonder Horse," and named Comet in the show, with the implication that he was the smartest character on the show. In fact, "Comet" was actually portrayed by four separate horses, with the horse being used in any particular scene depending on the type of action Comet was expected to perform.

Lord Bowler is based on Lord Baltimore from Butch Cassidy and the Sundance Kid (1969).

Peter Hutter always greeted Brisco the same way, no matter what condition he was in: "Hello Brisssssco."

Christian Clemenson could never get used to riding on horses. But since Socrates was supposed to be a studious sort, he thought it was entirely in character and helped his performance.

Was the last production to film on the Laramie Street backlot set at Warner Brothers Studios. It was actually being torn down to accommodate a post-production sound facility during filming of the show, which was used to rerecord the sound for episodes whose audio tracks were disrupted by the construction of said facility.

Dixie Cousins' theme song, "I'm Going to File My Claim," was written for Marilyn Monroe to sing in River of No Return (1954). Monroe is an obvious inspiration for the Dixie character.

Pete Hutter had an obsession with his gun, which he nicknamed "Pete's Piece."

Brisco often used the alias Roscoe Merriweather, which he first invented in The Adventures of Brisco County, Jr.: Pilot (1993).

John Astin (Professor Wickwire) appeared as a villain-of-the-week on The Wild Wild West: The Night of the Tartar (1967), a series which was an obvious inspiration for this one.

Kelly Rutherford, Dixie Cousins, is not only found in a saloon/bar in this series, tended bar in Homefront (1991), produced at the same time.

Pete Hutter dies in several episodes but is always brought back either in that episode or a future episode with outlandish but funny reasoning as to why he is still alive.

According to writer Carlton Cuse, had the series been renewed for a second season, the main plot line would have centered around Brisco County Jr. eventually settling down, marrying Dixie Cousins, and becoming a sheriff to a town populated by all sorts of characters with similar characteristics to many of the guest characters from Season One.

By the end of the show's run, only nine of the thirteen members of John Bly's gang were shown to be apprehended or killed. They were: Big Smith, Jack Randolph, Brett Bones, Blackbeard LaCutte, Juno Dawkins, Doc McCoy, Ned Zed, Pepe Bendix, and Bly himself. The remaining four gang members are unaccounted for, although it is implied that they were captured at some point before The Adventures of Brisco County, Jr.: Bye Bly (1994), based on dialog between Brisco and Bowler where they mention that Pepe Bendix is the last remaining gang member.

Lord Bowler has many aliases. His real name is James Lonefeather, this was first revealed in The Adventures of Brisco County, Jr.: Hard Rock (1994).

Dixie Cousins' real name is Myra Simon.

According to The Adventures of Brisco County, Jr.: High Treason: Part 1 (1994), Pete Hutter's middle name is Leviticus.