The series ended when Coen van Vrijberghe de Coningh, who played Johnnie Flodder, died of a cardiac arrest while performing with the other Flodder actors at a corporate party.

Both Huub Stapel (Johnnie) and 'René van 't Hof' (son Kees) did not want to reprise their movie roles in the television series, so their parts were re-cast with Coen van Vrijberghe de Coningh and Stefan de Walle. This also caused an abrupt personality change in both characters. Johnnie had been a tough guy and ladies' man in the movies, but became more of a smart-mouthed hustler in the series; Kees had always been portrayed as a wimpy loser, but he was re-invented as a good-natured idiot for the series.

The series took the premise of the first Flodder (1986) movie, but basically ignored the continuity of the first two films. For example, the family's grandfather is alive again after dying in the first movie; Sjakie (Lou Landré') does not seem to have undergone his accidental transgender surgery from the second movie; and the neighbors, Clarissa and Arie Neuteboom (Lettie Oosthoek and Bert André) are now called Tilly and Ed.

Several of the actors spoke in very different working class accents while portraying members of the Flodder family. Coen van Vrijberghe de Coningh spoke in a thick Amsterdam accent while Stefan de Walle used the typical working class accent from The Hague. Tatjana Simic spoke with a very thick Rotterdam accent in the first movie, which was toned down in the series. This could be explained because it's mentioned on several occasions that the Flodder children all have a different father.

Horace Cohen, who portrayed Henkie Flodder in the first movie, makes two brief appearances in the last season of the show, in the episodes "huisarrest" and "egotrip".

No-one is ever seen actually swimming in the pool in the Flodders garden. This is because the pool was built in the First Floor Features studios and therefore was only several centimeters deep.

The neighborhood in which the Flodders live was in fact a set, built on the outdoor terrain of First Floor Features, near the city of Almere. By 1995, it consisted of 12 fake empty villas, except for the Flodder villa, which had a decorated hallway. All shots inside any of the houses were done in an indoor studio. The illusion of the Zonnedael district being far larger was created by making creative camera angles or even by mirroring the footage. Some scenes had Coen van Vrijberghe de Coningh and his passenger change seats, with Van Vrijberghe de Coningh holding a fake wheel while his "passenger" was actually driving the car with a hidden wheel. The set was abandoned by First Floor Features in 1999.

After the show's end in 1998, Veronica and later Yorin and RTL kept broadcasting the old episodes from time to time, continuing to do so up until 2017 and even buying the rights when First Floor Features went bankrupt. Several lead actors showed discontent about the repeats over the years, since the show's success resulted in typecasting and threatened a loss of income for them, especially when RTL initially did not pay them any compensation for the repeats. This even resulted in a lawsuit in 2008, which the actors and the heirs of Coen van Vrijberghe de Coningh won in 2011.

Johnny is the only Flodder family member whose age is clearly mentioned: during the first season Ma claims Johnny is 27 years old. In truth, Coen van Vrijberghe de Coningh was in his forties when he played the role. He was 47 when he died.

Producers Dick Maas and Laurens Geels intended to end the show after three seasons, planning a three-part finale, which they eventually turned into the movie Flodder 3 (1995). Later it was decided to make more episodes anyway.

Although Huub Stapel refused to return as 'Johnnie Flodder' in the TV series, he did have a brief guest role in the fifth season episode "Egotrip".