The catering van in the dinner scene reads Arkoff and Corman, Industrial Caterers, a reference to American International Pictures producer Samuel Z. Arkoff and director Roger Corman (neither of whom was involved in the original Attack of the 50 Foot Woman (1958), which was released by Allied Artists).

Paul Benedict, who plays a doctor hired to cure Nancy's gigantism, suffered for several years from acromegaly, an overproduction of growth hormone. It has been speculated that the producers knew of Benedict's former condition and that his casting was an in-joke.

Daryl Hannah wasn't interested at first in remaking an old "Grade Z" science fiction movie, but liked the script, and saw it as an allegory about feminism.

A TV movie for the HBO network.